Etiology and Treatment of Oral Recurrent Aphthous Stomatitis

BACKGROUND AND OBJECTIVE: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal diseases. Nowadays, the majority of published systematic reviews is increasing, hence healthcare decision makers are meeting much evidence in order to solving their clinical problems. The aim of the...

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Autores principales:	N Navabi, H Kamiabi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	umbrella review systematic review recurrent aphthous stomatitis oral ulcer. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a51ee52ca7d54dcaba6207d747cd9893
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spelling	oai:doaj.org-article:a51ee52ca7d54dcaba6207d747cd98932021-11-09T10:15:55ZEtiology and Treatment of Oral Recurrent Aphthous Stomatitis1561-41072251-7170https://doaj.org/article/a51ee52ca7d54dcaba6207d747cd98932020-03-01T00:00:00Zhttp://jbums.org/article-1-8864-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal diseases. Nowadays, the majority of published systematic reviews is increasing, hence healthcare decision makers are meeting much evidence in order to solving their clinical problems. The aim of the present umbrella review was to report current knowledge on etiology, diagnosis and treatment of RAS. METHODS: In the present umbrella review, we searched for systematic reviews using PubMed, ISI web of science, Scopus and the Cochrane Library from the beginning of 2000 up to end of 2018 using the following key words: “systematic review” “Meta-analysis” and “aphthous”. Two investigators independently screened, extracted the data, and quality appraised the papers using Joanna Bridges Institute (JBI) protocol. FINDINGS: Finally, 18 systematic reviews were included (8 on etiology and 10 on treatment). Out of these papers, findings of 6 meta-analysis suggested that hematologic deficiencies, interleukin polymorphism and helicobacter pylori seem to have association with RAS, however for treatment of RAS (including: topical, systemic and laser therapy) there were not conclusive findings. CONCLUSION: According to results of this study, hematologic deficiencies, interleukin polymorphism and helicobacter pylori are among the novel etiologies of recurrent aphthous stomatitis, although there is no presented unique and conclusive treatment option for this common lesion yet.N NavabiH KamiabiBabol University of Medical Sciencesarticleumbrella reviewsystematic reviewrecurrent aphthous stomatitisoral ulcer.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 380-387 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	umbrella review systematic review recurrent aphthous stomatitis oral ulcer. Medicine R Medicine (General) R5-920
spellingShingle	umbrella review systematic review recurrent aphthous stomatitis oral ulcer. Medicine R Medicine (General) R5-920 N Navabi H Kamiabi Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
description	BACKGROUND AND OBJECTIVE: Recurrent Aphthous Stomatitis (RAS) is one of the most common oral mucosal diseases. Nowadays, the majority of published systematic reviews is increasing, hence healthcare decision makers are meeting much evidence in order to solving their clinical problems. The aim of the present umbrella review was to report current knowledge on etiology, diagnosis and treatment of RAS. METHODS: In the present umbrella review, we searched for systematic reviews using PubMed, ISI web of science, Scopus and the Cochrane Library from the beginning of 2000 up to end of 2018 using the following key words: “systematic review” “Meta-analysis” and “aphthous”. Two investigators independently screened, extracted the data, and quality appraised the papers using Joanna Bridges Institute (JBI) protocol. FINDINGS: Finally, 18 systematic reviews were included (8 on etiology and 10 on treatment). Out of these papers, findings of 6 meta-analysis suggested that hematologic deficiencies, interleukin polymorphism and helicobacter pylori seem to have association with RAS, however for treatment of RAS (including: topical, systemic and laser therapy) there were not conclusive findings. CONCLUSION: According to results of this study, hematologic deficiencies, interleukin polymorphism and helicobacter pylori are among the novel etiologies of recurrent aphthous stomatitis, although there is no presented unique and conclusive treatment option for this common lesion yet.
format	article
author	N Navabi H Kamiabi
author_facet	N Navabi H Kamiabi
author_sort	N Navabi
title	Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
title_short	Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
title_full	Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
title_fullStr	Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
title_full_unstemmed	Etiology and Treatment of Oral Recurrent Aphthous Stomatitis
title_sort	etiology and treatment of oral recurrent aphthous stomatitis
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/a51ee52ca7d54dcaba6207d747cd9893
work_keys_str_mv	AT nnavabi etiologyandtreatmentoforalrecurrentaphthousstomatitis AT hkamiabi etiologyandtreatmentoforalrecurrentaphthousstomatitis
_version_	1718441135389540352

Etiology and Treatment of Oral Recurrent Aphthous Stomatitis

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