Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus

Bai-Rong Wang,1,2 Jun-Teng Yao,2 Hui Zheng,1 Quan-Min Li1 1Department of Endocrinology, Medical College of Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China; PLA Rocket Force Characteristic Medical Center, Beijing, 100088, People’s Republic of China; 2Departm...

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Autores principales:	Wang BR, Yao JT, Zheng H, Li QM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes mellitus glycated albumin glycosylated hemoglobin blood glucose control blood glucose fluctuation Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/a521255d5f60456d801bada9c321dd45
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spelling	oai:doaj.org-article:a521255d5f60456d801bada9c321dd452021-12-02T17:30:30ZAssociation of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/a521255d5f60456d801bada9c321dd452021-04-01T00:00:00Zhttps://www.dovepress.com/association-of-glycated-albuminglycosylated-hemoglobin-ratio-with-bloo-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Bai-Rong Wang,1,2 Jun-Teng Yao,2 Hui Zheng,1 Quan-Min Li1 1Department of Endocrinology, Medical College of Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China; PLA Rocket Force Characteristic Medical Center, Beijing, 100088, People’s Republic of China; 2Department of Endocrinology, Jinjiang Municipal Hospital, Jinjiang, 362200, People’s Republic of ChinaCorrespondence: Quan-Min LiPLA Rocket Force Characteristic Medical Center, Beijing, 100088, People’s Republic of ChinaTel +86 10 66927601Email liquanming369@163.comObjective: This study aimed to investigate the association of the glycated albumin (GA)/glycosylated hemoglobin (HbA1c) ratio with the mean amplitude of glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM).Methods: A total of 102 patients with T2DM who were first treated in Jinjiang Hospital of Fujian Province were enrolled in this study. The patients’ general clinical data, including HbA1c, GA, fasting blood glucose, and fasting and peak C-peptide values upon diagnosis and after one year of follow-up, were collected, and their MAGE was calculated.Results: With the increase of the GA/HbA1c ratio at baseline, the patients’ fasting and peak C-peptide values decreased gradually from baseline to follow-up, while their MAGE, HbA1c, and fasting blood glucose increased gradually. A regression analysis demonstrated that the baseline MAGE was independently positively correlated with the GA/HbA1c ratio. A Cox regression analysis demonstrated that a baseline GA/HbA1c ratio of > 2.78 was an independent risk factor for poor fasting blood glucose and HbA1c.Conclusion: The GA/HbA1c ratio is closely related to the MAGE and islet function in patients with T2DM.Keywords: type 2 diabetes mellitus, glycated albumin, glycosylated hemoglobin, blood glucose control, blood glucose fluctuationWang BRYao JTZheng HLi QMDove Medical Pressarticletype 2 diabetes mellitusglycated albuminglycosylated hemoglobinblood glucose controlblood glucose fluctuationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1809-1815 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus glycated albumin glycosylated hemoglobin blood glucose control blood glucose fluctuation Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes mellitus glycated albumin glycosylated hemoglobin blood glucose control blood glucose fluctuation Specialties of internal medicine RC581-951 Wang BR Yao JT Zheng H Li QM Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
description	Bai-Rong Wang,1,2 Jun-Teng Yao,2 Hui Zheng,1 Quan-Min Li1 1Department of Endocrinology, Medical College of Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China; PLA Rocket Force Characteristic Medical Center, Beijing, 100088, People’s Republic of China; 2Department of Endocrinology, Jinjiang Municipal Hospital, Jinjiang, 362200, People’s Republic of ChinaCorrespondence: Quan-Min LiPLA Rocket Force Characteristic Medical Center, Beijing, 100088, People’s Republic of ChinaTel +86 10 66927601Email liquanming369@163.comObjective: This study aimed to investigate the association of the glycated albumin (GA)/glycosylated hemoglobin (HbA1c) ratio with the mean amplitude of glycemic excursion (MAGE) in type 2 diabetes mellitus (T2DM).Methods: A total of 102 patients with T2DM who were first treated in Jinjiang Hospital of Fujian Province were enrolled in this study. The patients’ general clinical data, including HbA1c, GA, fasting blood glucose, and fasting and peak C-peptide values upon diagnosis and after one year of follow-up, were collected, and their MAGE was calculated.Results: With the increase of the GA/HbA1c ratio at baseline, the patients’ fasting and peak C-peptide values decreased gradually from baseline to follow-up, while their MAGE, HbA1c, and fasting blood glucose increased gradually. A regression analysis demonstrated that the baseline MAGE was independently positively correlated with the GA/HbA1c ratio. A Cox regression analysis demonstrated that a baseline GA/HbA1c ratio of > 2.78 was an independent risk factor for poor fasting blood glucose and HbA1c.Conclusion: The GA/HbA1c ratio is closely related to the MAGE and islet function in patients with T2DM.Keywords: type 2 diabetes mellitus, glycated albumin, glycosylated hemoglobin, blood glucose control, blood glucose fluctuation
format	article
author	Wang BR Yao JT Zheng H Li QM
author_facet	Wang BR Yao JT Zheng H Li QM
author_sort	Wang BR
title	Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
title_short	Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
title_full	Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
title_fullStr	Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus
title_sort	association of glycated albumin/glycosylated hemoglobin ratio with blood glucose fluctuation and long-term blood glucose control in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a521255d5f60456d801bada9c321dd45
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Association of Glycated Albumin/Glycosylated Hemoglobin Ratio with Blood Glucose Fluctuation and Long-Term Blood Glucose Control in Patients with Type 2 Diabetes Mellitus

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