Development of a genetic sensor that eliminates p53 deficient cells

TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene, which can activate the drug Ganciclovir, resultin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jovan Mircetic, Antje Dietrich, Maciej Paszkowski-Rogacz, Mechthild Krause, Frank Buchholz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a523286eef224f22b2c54b9effda2530
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a523286eef224f22b2c54b9effda2530
record_format	dspace
spelling	oai:doaj.org-article:a523286eef224f22b2c54b9effda25302021-12-02T15:38:46ZDevelopment of a genetic sensor that eliminates p53 deficient cells10.1038/s41467-017-01688-w2041-1723https://doaj.org/article/a523286eef224f22b2c54b9effda25302017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01688-whttps://doaj.org/toc/2041-1723TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene, which can activate the drug Ganciclovir, resulting in cell death.Jovan MirceticAntje DietrichMaciej Paszkowski-RogaczMechthild KrauseFrank BuchholzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jovan Mircetic Antje Dietrich Maciej Paszkowski-Rogacz Mechthild Krause Frank Buchholz Development of a genetic sensor that eliminates p53 deficient cells
description	TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene, which can activate the drug Ganciclovir, resulting in cell death.
format	article
author	Jovan Mircetic Antje Dietrich Maciej Paszkowski-Rogacz Mechthild Krause Frank Buchholz
author_facet	Jovan Mircetic Antje Dietrich Maciej Paszkowski-Rogacz Mechthild Krause Frank Buchholz
author_sort	Jovan Mircetic
title	Development of a genetic sensor that eliminates p53 deficient cells
title_short	Development of a genetic sensor that eliminates p53 deficient cells
title_full	Development of a genetic sensor that eliminates p53 deficient cells
title_fullStr	Development of a genetic sensor that eliminates p53 deficient cells
title_full_unstemmed	Development of a genetic sensor that eliminates p53 deficient cells
title_sort	development of a genetic sensor that eliminates p53 deficient cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a523286eef224f22b2c54b9effda2530
work_keys_str_mv	AT jovanmircetic developmentofageneticsensorthateliminatesp53deficientcells AT antjedietrich developmentofageneticsensorthateliminatesp53deficientcells AT maciejpaszkowskirogacz developmentofageneticsensorthateliminatesp53deficientcells AT mechthildkrause developmentofageneticsensorthateliminatesp53deficientcells AT frankbuchholz developmentofageneticsensorthateliminatesp53deficientcells
_version_	1718386132330217472

Development of a genetic sensor that eliminates p53 deficient cells

Ejemplares similares