Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer

The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistan...

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Autores principales:	Chengfei Liu, Wei Lou, Joy C. Yang, Liangren Liu, Cameron M. Armstrong, Alan P. Lombard, Ruining Zhao, Onika D. V. Noel, Clifford G. Tepper, Hong-Wu Chen, Marc Dall’Era, Christopher P. Evans, Allen C. Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5238e051d1c4725877bc665524a75c3
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spelling	oai:doaj.org-article:a5238e051d1c4725877bc665524a75c32021-12-02T15:33:35ZProteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer10.1038/s41467-018-07178-x2041-1723https://doaj.org/article/a5238e051d1c4725877bc665524a75c32018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07178-xhttps://doaj.org/toc/2041-1723The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.Chengfei LiuWei LouJoy C. YangLiangren LiuCameron M. ArmstrongAlan P. LombardRuining ZhaoOnika D. V. NoelClifford G. TepperHong-Wu ChenMarc Dall’EraChristopher P. EvansAllen C. GaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chengfei Liu Wei Lou Joy C. Yang Liangren Liu Cameron M. Armstrong Alan P. Lombard Ruining Zhao Onika D. V. Noel Clifford G. Tepper Hong-Wu Chen Marc Dall’Era Christopher P. Evans Allen C. Gao Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
description	The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.
format	article
author	Chengfei Liu Wei Lou Joy C. Yang Liangren Liu Cameron M. Armstrong Alan P. Lombard Ruining Zhao Onika D. V. Noel Clifford G. Tepper Hong-Wu Chen Marc Dall’Era Christopher P. Evans Allen C. Gao
author_facet	Chengfei Liu Wei Lou Joy C. Yang Liangren Liu Cameron M. Armstrong Alan P. Lombard Ruining Zhao Onika D. V. Noel Clifford G. Tepper Hong-Wu Chen Marc Dall’Era Christopher P. Evans Allen C. Gao
author_sort	Chengfei Liu
title	Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
title_short	Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
title_full	Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
title_fullStr	Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
title_full_unstemmed	Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
title_sort	proteostasis by stub1/hsp70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a5238e051d1c4725877bc665524a75c3
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Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer

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