Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.

Patients with sickle cell anemia (SCA) have usually lower diastolic, systolic and mean blood pressure (BP) than the general population. However, BP values ≥120/70 mmHg considerably increase the risk for acute and chronic complications in SCA. The aim of this study was to identify biological factors...

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Autores principales:	Yann Lamarre, Marie-Laure Lalanne-Mistrih, Marc Romana, Nathalie Lemonne, Daniele Mougenel, Xavier Waltz, Benoît Tressières, Maryse Etienne-Julan, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Philippe Connes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a52439f933c34dae99c46de2214bd135
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spelling	oai:doaj.org-article:a52439f933c34dae99c46de2214bd1352021-11-18T07:41:52ZMale gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.1932-620310.1371/journal.pone.0066004https://doaj.org/article/a52439f933c34dae99c46de2214bd1352013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785465/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Patients with sickle cell anemia (SCA) have usually lower diastolic, systolic and mean blood pressure (BP) than the general population. However, BP values ≥120/70 mmHg considerably increase the risk for acute and chronic complications in SCA. The aim of this study was to identify biological factors associated with relative hypertension in adults with SCA. We compared the hematological, lipid and hemolytic profiles, as well as blood viscosity, between SCA patients with normal BP (<120/70 mmHg, n = 54) and those with relative hypertension (BP≥120/70 mmHg, n = 43). Our results demonstrated that male gender (OR: 3.49; 95%CI 1.20 to 10.16, p<0.05), triglycerides (OR: 9.19; 95% CI 2.29 to 36.95, p<0.01), blood viscosity (OR: 1.35; 95% CI 1.01 to 1.81, p<0.05) and body mass index (OR: 1.37; 95% CI 1.14 to 1.64, p<0.01) were independent risks factors for relative hypertension in SCA. No association was found between the BP status and the positive history of painful vaso-occlusive crisis or acute chest syndrome. An association between triglycerides level and the occurrence of these two major acute complications was detected. Our study suggests that male gender, increased triglycerides level, BMI and blood viscosity could increase the risk for developing relative hypertension in SCA. In addition, our results support a role of moderately elevated triglycerides in the pathophysiology of vaso-occlusive events.Yann LamarreMarie-Laure Lalanne-MistrihMarc RomanaNathalie LemonneDaniele MougenelXavier WaltzBenoît TressièresMaryse Etienne-JulanVanessa TarerMarie-Dominique Hardy-DessourcesPhilippe ConnesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66004 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yann Lamarre Marie-Laure Lalanne-Mistrih Marc Romana Nathalie Lemonne Daniele Mougenel Xavier Waltz Benoît Tressières Maryse Etienne-Julan Vanessa Tarer Marie-Dominique Hardy-Dessources Philippe Connes Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
description	Patients with sickle cell anemia (SCA) have usually lower diastolic, systolic and mean blood pressure (BP) than the general population. However, BP values ≥120/70 mmHg considerably increase the risk for acute and chronic complications in SCA. The aim of this study was to identify biological factors associated with relative hypertension in adults with SCA. We compared the hematological, lipid and hemolytic profiles, as well as blood viscosity, between SCA patients with normal BP (<120/70 mmHg, n = 54) and those with relative hypertension (BP≥120/70 mmHg, n = 43). Our results demonstrated that male gender (OR: 3.49; 95%CI 1.20 to 10.16, p<0.05), triglycerides (OR: 9.19; 95% CI 2.29 to 36.95, p<0.01), blood viscosity (OR: 1.35; 95% CI 1.01 to 1.81, p<0.05) and body mass index (OR: 1.37; 95% CI 1.14 to 1.64, p<0.01) were independent risks factors for relative hypertension in SCA. No association was found between the BP status and the positive history of painful vaso-occlusive crisis or acute chest syndrome. An association between triglycerides level and the occurrence of these two major acute complications was detected. Our study suggests that male gender, increased triglycerides level, BMI and blood viscosity could increase the risk for developing relative hypertension in SCA. In addition, our results support a role of moderately elevated triglycerides in the pathophysiology of vaso-occlusive events.
format	article
author	Yann Lamarre Marie-Laure Lalanne-Mistrih Marc Romana Nathalie Lemonne Daniele Mougenel Xavier Waltz Benoît Tressières Maryse Etienne-Julan Vanessa Tarer Marie-Dominique Hardy-Dessources Philippe Connes
author_facet	Yann Lamarre Marie-Laure Lalanne-Mistrih Marc Romana Nathalie Lemonne Daniele Mougenel Xavier Waltz Benoît Tressières Maryse Etienne-Julan Vanessa Tarer Marie-Dominique Hardy-Dessources Philippe Connes
author_sort	Yann Lamarre
title	Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
title_short	Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
title_full	Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
title_fullStr	Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
title_full_unstemmed	Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
title_sort	male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a52439f933c34dae99c46de2214bd135
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Male gender, increased blood viscosity, body mass index and triglyceride levels are independently associated with systemic relative hypertension in sickle cell anemia.

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