Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Boguang Yang, Kongchang Wei, Claudia Loebel, Kunyu Zhang, Qian Feng, Rui Li, Siu Hong Dexter Wong, Xiayi Xu, Chunhon Lau, Xiaoyu Chen, Pengchao Zhao, Chao Yin, Jason A. Burdick, Yi Wang, Liming Bian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/a5253e196b884f9e8779742f7f16765a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and differentiation.