Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and...

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Autores principales:	Boguang Yang, Kongchang Wei, Claudia Loebel, Kunyu Zhang, Qian Feng, Rui Li, Siu Hong Dexter Wong, Xiayi Xu, Chunhon Lau, Xiaoyu Chen, Pengchao Zhao, Chao Yin, Jason A. Burdick, Yi Wang, Liming Bian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5253e196b884f9e8779742f7f16765a
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spelling	oai:doaj.org-article:a5253e196b884f9e8779742f7f16765a2021-12-02T17:30:39ZEnhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics10.1038/s41467-021-23120-02041-1723https://doaj.org/article/a5253e196b884f9e8779742f7f16765a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23120-0https://doaj.org/toc/2041-17233D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and differentiation.Boguang YangKongchang WeiClaudia LoebelKunyu ZhangQian FengRui LiSiu Hong Dexter WongXiayi XuChunhon LauXiaoyu ChenPengchao ZhaoChao YinJason A. BurdickYi WangLiming BianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boguang Yang Kongchang Wei Claudia Loebel Kunyu Zhang Qian Feng Rui Li Siu Hong Dexter Wong Xiayi Xu Chunhon Lau Xiaoyu Chen Pengchao Zhao Chao Yin Jason A. Burdick Yi Wang Liming Bian Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
description	3D culture systems can provide critical insights into cellular behaviour. Here, the authors study the binding timescale of dynamic crosslinks and the conjugation stability of cell-adhesive ligands in cell–hydrogel network interactions to evaluate the impact on stem cell behaviour, mechanosensing and differentiation.
format	article
author	Boguang Yang Kongchang Wei Claudia Loebel Kunyu Zhang Qian Feng Rui Li Siu Hong Dexter Wong Xiayi Xu Chunhon Lau Xiaoyu Chen Pengchao Zhao Chao Yin Jason A. Burdick Yi Wang Liming Bian
author_facet	Boguang Yang Kongchang Wei Claudia Loebel Kunyu Zhang Qian Feng Rui Li Siu Hong Dexter Wong Xiayi Xu Chunhon Lau Xiaoyu Chen Pengchao Zhao Chao Yin Jason A. Burdick Yi Wang Liming Bian
author_sort	Boguang Yang
title	Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
title_short	Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
title_full	Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
title_fullStr	Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
title_full_unstemmed	Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics
title_sort	enhanced mechanosensing of cells in synthetic 3d matrix with controlled biophysical dynamics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a5253e196b884f9e8779742f7f16765a
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_version_	1718380746859610112

Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

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