Bovine polledness--an autosomal dominant trait with allelic heterogeneity.

The persistent horns are an important trait of speciation for the family Bovidae with complex morphogenesis taking place briefly after birth. The polledness is highly favourable in modern cattle breeding systems but serious animal welfare issues urge for a solution in the production of hornless catt...

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Autores principales:	Ivica Medugorac, Doris Seichter, Alexander Graf, Ingolf Russ, Helmut Blum, Karl Heinrich Göpel, Sophie Rothammer, Martin Förster, Stefan Krebs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a527f6b96d574498b2f0d3851f7732cf
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spelling	oai:doaj.org-article:a527f6b96d574498b2f0d3851f7732cf2021-11-18T07:14:43ZBovine polledness--an autosomal dominant trait with allelic heterogeneity.1932-620310.1371/journal.pone.0039477https://doaj.org/article/a527f6b96d574498b2f0d3851f7732cf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737241/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The persistent horns are an important trait of speciation for the family Bovidae with complex morphogenesis taking place briefly after birth. The polledness is highly favourable in modern cattle breeding systems but serious animal welfare issues urge for a solution in the production of hornless cattle other than dehorning. Although the dominant inhibition of horn morphogenesis was discovered more than 70 years ago, and the causative mutation was mapped almost 20 years ago, its molecular nature remained unknown. Here, we report allelic heterogeneity of the POLLED locus. First, we mapped the POLLED locus to a ∼381-kb interval in a multi-breed case-control design. Targeted re-sequencing of an enlarged candidate interval (547 kb) in 16 sires with known POLLED genotype did not detect a common allele associated with polled status. In eight sires of Alpine and Scottish origin (four polled versus four horned), we identified a single candidate mutation, a complex 202 bp insertion-deletion event that showed perfect association to the polled phenotype in various European cattle breeds, except Holstein-Friesian. The analysis of the same candidate interval in eight Holsteins identified five candidate variants which segregate as a 260 kb haplotype also perfectly associated with the POLLED gene without recombination or interference with the 202 bp insertion-deletion. We further identified bulls which are progeny tested as homozygous polled but bearing both, 202 bp insertion-deletion and Friesian haplotype. The distribution of genotypes of the two putative POLLED alleles in large semi-random sample (1,261 animals) supports the hypothesis of two independent mutations.Ivica MedugoracDoris SeichterAlexander GrafIngolf RussHelmut BlumKarl Heinrich GöpelSophie RothammerMartin FörsterStefan KrebsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39477 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivica Medugorac Doris Seichter Alexander Graf Ingolf Russ Helmut Blum Karl Heinrich Göpel Sophie Rothammer Martin Förster Stefan Krebs Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
description	The persistent horns are an important trait of speciation for the family Bovidae with complex morphogenesis taking place briefly after birth. The polledness is highly favourable in modern cattle breeding systems but serious animal welfare issues urge for a solution in the production of hornless cattle other than dehorning. Although the dominant inhibition of horn morphogenesis was discovered more than 70 years ago, and the causative mutation was mapped almost 20 years ago, its molecular nature remained unknown. Here, we report allelic heterogeneity of the POLLED locus. First, we mapped the POLLED locus to a ∼381-kb interval in a multi-breed case-control design. Targeted re-sequencing of an enlarged candidate interval (547 kb) in 16 sires with known POLLED genotype did not detect a common allele associated with polled status. In eight sires of Alpine and Scottish origin (four polled versus four horned), we identified a single candidate mutation, a complex 202 bp insertion-deletion event that showed perfect association to the polled phenotype in various European cattle breeds, except Holstein-Friesian. The analysis of the same candidate interval in eight Holsteins identified five candidate variants which segregate as a 260 kb haplotype also perfectly associated with the POLLED gene without recombination or interference with the 202 bp insertion-deletion. We further identified bulls which are progeny tested as homozygous polled but bearing both, 202 bp insertion-deletion and Friesian haplotype. The distribution of genotypes of the two putative POLLED alleles in large semi-random sample (1,261 animals) supports the hypothesis of two independent mutations.
format	article
author	Ivica Medugorac Doris Seichter Alexander Graf Ingolf Russ Helmut Blum Karl Heinrich Göpel Sophie Rothammer Martin Förster Stefan Krebs
author_facet	Ivica Medugorac Doris Seichter Alexander Graf Ingolf Russ Helmut Blum Karl Heinrich Göpel Sophie Rothammer Martin Förster Stefan Krebs
author_sort	Ivica Medugorac
title	Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
title_short	Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
title_full	Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
title_fullStr	Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
title_full_unstemmed	Bovine polledness--an autosomal dominant trait with allelic heterogeneity.
title_sort	bovine polledness--an autosomal dominant trait with allelic heterogeneity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a527f6b96d574498b2f0d3851f7732cf
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Bovine polledness--an autosomal dominant trait with allelic heterogeneity.

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