Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.

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Autores principales:	Jingjing Liang, Jun Lyu, Meng Zhao, Dan Li, Mingzhu Zheng, Yan Fang, Fangzhu Zhao, Jun Lou, Chuansheng Guo, Lie Wang, Di Wang, Wanli Liu, Linrong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a52a6735a643439889e80aa2ad51b908
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spelling	oai:doaj.org-article:a52a6735a643439889e80aa2ad51b9082021-12-02T15:38:42ZTespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors10.1038/ncomms157322041-1723https://doaj.org/article/a52a6735a643439889e80aa2ad51b9082017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15732https://doaj.org/toc/2041-1723The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.Jingjing LiangJun LyuMeng ZhaoDan LiMingzhu ZhengYan FangFangzhu ZhaoJun LouChuansheng GuoLie WangDi WangWanli LiuLinrong LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingjing Liang Jun Lyu Meng Zhao Dan Li Mingzhu Zheng Yan Fang Fangzhu Zhao Jun Lou Chuansheng Guo Lie Wang Di Wang Wanli Liu Linrong Lu Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
description	The thymocyte development protein Tespa1 is known to translate T cell receptor signals by affecting the calcium signalling cascade, but it is not clear how. Here the authors show that Tespa1 recruits IP3R1 to the TCR signalling complex.
format	article
author	Jingjing Liang Jun Lyu Meng Zhao Dan Li Mingzhu Zheng Yan Fang Fangzhu Zhao Jun Lou Chuansheng Guo Lie Wang Di Wang Wanli Liu Linrong Lu
author_facet	Jingjing Liang Jun Lyu Meng Zhao Dan Li Mingzhu Zheng Yan Fang Fangzhu Zhao Jun Lou Chuansheng Guo Lie Wang Di Wang Wanli Liu Linrong Lu
author_sort	Jingjing Liang
title	Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
title_short	Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
title_full	Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
title_fullStr	Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
title_full_unstemmed	Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
title_sort	tespa1 regulates t cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a52a6735a643439889e80aa2ad51b908
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Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

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