Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Runping Su,1 Li Yang,2 Yue Wang,1 Shanshan Yu,1 Yu Guo,1 Jiayu Deng,1 Qianqian Zhao,1 Xiangqun Jin1 1Department of Pharmaceutics, School of Pharmacy, 2Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, Chin...

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Autores principales:	Su R, Yang L, Wang Y, Yu S, Guo Y, Deng J, Zhao Q, Jin X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	response surface methodology nano-emulsions optimization particle size polydispersity index Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a52d851b5b474e3ba80e4e82da2a5d76
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spelling	oai:doaj.org-article:a52d851b5b474e3ba80e4e82da2a5d762021-12-02T00:39:21ZFormulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB1178-2013https://doaj.org/article/a52d851b5b474e3ba80e4e82da2a5d762017-07-01T00:00:00Zhttps://www.dovepress.com/formulation-development-and-optimization-of-a-novel-octyldodecanol-bas-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Runping Su,1 Li Yang,2 Yue Wang,1 Shanshan Yu,1 Yu Guo,1 Jiayu Deng,1 Qianqian Zhao,1 Xiangqun Jin1 1Department of Pharmaceutics, School of Pharmacy, 2Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China Abstract: This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant (P>0.05) differences. Keywords: response surface methodology, nanoemulsions, optimization, particle size, polydispersity indexSu RYang LWang YYu SGuo YDeng JZhao QJin XDove Medical Pressarticleresponse surface methodologynano-emulsionsoptimizationparticle sizepolydispersity indexMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5203-5221 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	response surface methodology nano-emulsions optimization particle size polydispersity index Medicine (General) R5-920
spellingShingle	response surface methodology nano-emulsions optimization particle size polydispersity index Medicine (General) R5-920 Su R Yang L Wang Y Yu S Guo Y Deng J Zhao Q Jin X Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
description	Runping Su,1 Li Yang,2 Yue Wang,1 Shanshan Yu,1 Yu Guo,1 Jiayu Deng,1 Qianqian Zhao,1 Xiangqun Jin1 1Department of Pharmaceutics, School of Pharmacy, 2Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China Abstract: This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant (P>0.05) differences. Keywords: response surface methodology, nanoemulsions, optimization, particle size, polydispersity index
format	article
author	Su R Yang L Wang Y Yu S Guo Y Deng J Zhao Q Jin X
author_facet	Su R Yang L Wang Y Yu S Guo Y Deng J Zhao Q Jin X
author_sort	Su R
title	Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
title_short	Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
title_full	Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
title_fullStr	Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
title_full_unstemmed	Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB
title_sort	formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide iiib
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a52d851b5b474e3ba80e4e82da2a5d76
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Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

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