Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life

Myrte B Breukink,1,* Alexander JM Dingemans,1,* Anneke I den Hollander,1,2 Jan EE Keunen,1 Robert E MacLaren,3,4 Sascha Fauser,5 Giuseppe Querques,6 Carel B Hoyng,1 Susan M Downes,3,4 Camiel JF Boon1,7 1Department of Ophthalmology, 2Department of Human Genetics, Radboud University Medical Center, N...

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Autores principales:	Breukink MB, Dingemans AJM, den Hollander AI, Keunen JEE, MacLaren RE, Fauser S, Querques G, Hoyng CB, Downes SM, Boon CJF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Chronic Central Serous Chorioretinopathy Micropulse Laser NEI-VFQ-39 PDT Vision Related Quality of Life Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a52fb36a3923447f9ae48fc9a53801ca
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spelling	oai:doaj.org-article:a52fb36a3923447f9ae48fc9a53801ca2021-12-02T02:40:09ZChronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life1177-5483https://doaj.org/article/a52fb36a3923447f9ae48fc9a53801ca2016-12-01T00:00:00Zhttps://www.dovepress.com/chronic-central-serous-chorioretinopathy-long-term-follow-up-and-visio-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Myrte B Breukink,1,* Alexander JM Dingemans,1,* Anneke I den Hollander,1,2 Jan EE Keunen,1 Robert E MacLaren,3,4 Sascha Fauser,5 Giuseppe Querques,6 Carel B Hoyng,1 Susan M Downes,3,4 Camiel JF Boon1,7 1Department of Ophthalmology, 2Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; 3Oxford Eye Hospital, Oxford University Hospitals NHS Trust, 4Nuffield Laboratory of Ophthalmology and NIHR Biomedical Research Centre, Department of Clinical Neurosciences, University of Oxford, Oxford, UK; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France; 7Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands *These authors contributed equally to this work Purpose: To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC).Materials and methods: This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual Function Questionnaire [NEI-VFQ]-39) were analyzed.Results: Mean visual acuity showed a significant decline over time of 0.16 logarithm of minimum angle of resolution ([logMAR] range: -0.22 to 1.3; P=0.009) after a mean follow-up period of 10.6 years. Also, patients reported lower vision-related quality of life based on the NEI-VFQ-39 for almost all categories compared to healthy controls. Macular atrophy was diagnosed more often on optical coherence tomography compared to other diagnostic entities. Retinal pigment epithelium detachments in the macula were documented on optical coherence tomography in 56% of the patients. A significant thinning of foveal thickness was measured over time compared to unaffected fellow eyes (P=0.002). On long-term follow-up, 13 eyes (37%) showed an increase in number of hot spots on fluorescein angiography.Conclusion: This study indicates that cCSC is a progressive disease in many patients, causing a progressive decline in visual acuity, accompanied by lower reported vision-related quality of life. In deciding whether or not to treat, the progressive nature of cCSC should be taken into account in this relatively young and often still professionally active patient group. Keywords: chronic central serous chorioretinopathy, micropulse laser, NEI-VFQ-39, PDT, vision-related quality of lifeBreukink MBDingemans AJMden Hollander AIKeunen JEEMacLaren REFauser SQuerques GHoyng CBDownes SMBoon CJFDove Medical PressarticleChronic Central Serous ChorioretinopathyMicropulse LaserNEI-VFQ-39PDTVision Related Quality of LifeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 39-46 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic Central Serous Chorioretinopathy Micropulse Laser NEI-VFQ-39 PDT Vision Related Quality of Life Ophthalmology RE1-994
spellingShingle	Chronic Central Serous Chorioretinopathy Micropulse Laser NEI-VFQ-39 PDT Vision Related Quality of Life Ophthalmology RE1-994 Breukink MB Dingemans AJM den Hollander AI Keunen JEE MacLaren RE Fauser S Querques G Hoyng CB Downes SM Boon CJF Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
description	Myrte B Breukink,1,* Alexander JM Dingemans,1,* Anneke I den Hollander,1,2 Jan EE Keunen,1 Robert E MacLaren,3,4 Sascha Fauser,5 Giuseppe Querques,6 Carel B Hoyng,1 Susan M Downes,3,4 Camiel JF Boon1,7 1Department of Ophthalmology, 2Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; 3Oxford Eye Hospital, Oxford University Hospitals NHS Trust, 4Nuffield Laboratory of Ophthalmology and NIHR Biomedical Research Centre, Department of Clinical Neurosciences, University of Oxford, Oxford, UK; 5Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany; 6Department of Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France; 7Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands *These authors contributed equally to this work Purpose: To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC).Materials and methods: This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual Function Questionnaire [NEI-VFQ]-39) were analyzed.Results: Mean visual acuity showed a significant decline over time of 0.16 logarithm of minimum angle of resolution ([logMAR] range: -0.22 to 1.3; P=0.009) after a mean follow-up period of 10.6 years. Also, patients reported lower vision-related quality of life based on the NEI-VFQ-39 for almost all categories compared to healthy controls. Macular atrophy was diagnosed more often on optical coherence tomography compared to other diagnostic entities. Retinal pigment epithelium detachments in the macula were documented on optical coherence tomography in 56% of the patients. A significant thinning of foveal thickness was measured over time compared to unaffected fellow eyes (P=0.002). On long-term follow-up, 13 eyes (37%) showed an increase in number of hot spots on fluorescein angiography.Conclusion: This study indicates that cCSC is a progressive disease in many patients, causing a progressive decline in visual acuity, accompanied by lower reported vision-related quality of life. In deciding whether or not to treat, the progressive nature of cCSC should be taken into account in this relatively young and often still professionally active patient group. Keywords: chronic central serous chorioretinopathy, micropulse laser, NEI-VFQ-39, PDT, vision-related quality of life
format	article
author	Breukink MB Dingemans AJM den Hollander AI Keunen JEE MacLaren RE Fauser S Querques G Hoyng CB Downes SM Boon CJF
author_facet	Breukink MB Dingemans AJM den Hollander AI Keunen JEE MacLaren RE Fauser S Querques G Hoyng CB Downes SM Boon CJF
author_sort	Breukink MB
title	Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
title_short	Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
title_full	Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
title_fullStr	Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
title_full_unstemmed	Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
title_sort	chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a52fb36a3923447f9ae48fc9a53801ca
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Chronic central serous chorioretinopathy: long-term follow-up and vision-related quality of life

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