Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome

Background. Genital prolapse (GP) and stress urinary incontinence (SUI) are characterized by a failure of connective tissue skeleton of the pelvic floor structures, and there are many risk factors in their pathogenesis. Metabolic syndrome (MS), which includes obesity and abnormalities in the lipid a...

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Autores principales:	Irina A. Lapina, Yulia E. Dobrokhotova, Vladislav V. Taranov, Tatiana G. Chirvon, Polina Volkova, Anastasia A. Malakhova
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	pelvic organ prolapse stress urinary incontinence metabolic syndrome endothelial dysfunction Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/a53055b3f11c4834919fe1edfaa024e1
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spelling	oai:doaj.org-article:a53055b3f11c4834919fe1edfaa024e12021-12-02T19:22:24ZComprehensive management of patients with pelvis organ prolapse and metabolic syndrome2079-56962079-583110.26442/20795696.2021.3.200962https://doaj.org/article/a53055b3f11c4834919fe1edfaa024e12021-08-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/76155/56749https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Background. Genital prolapse (GP) and stress urinary incontinence (SUI) are characterized by a failure of connective tissue skeleton of the pelvic floor structures, and there are many risk factors in their pathogenesis. Metabolic syndrome (MS), which includes obesity and abnormalities in the lipid and carbohydrate profile, contributes to the initiation of pelvic organ prolapse (POP) due to increased intra-abdominal pressure and the presence of comorbidities. Endothelial dysfunction associated with MS aggravates the existing metabolic disorders, resulting in the formation of a vicious circle and an increase in the likelihood of recurrence of genital prolapse symptoms and НМ during tension in the postoperative period. Aim. The search for rational algorithms for the comprehensive management of patients with POP and MS. Materials and methods. A comparative analysis of effectiveness of treatment with the use of surgical method or drugs which affect the metabolic profile in patients with GP and SUI was carried out. Results. Drugs which contribute the restoration of lipid and carbohydrate profiles, and microcirculatory vasculature normalization, attenuate negative effects of MS components on the integrity of pelvic floor structures. Comprehensive management of patients with POP and MS with surgical correction of GP and SUI, as well as the use of drugs affecting metabolism, is highly effective and predictive in regard to POP severity and the risk of recurrence of clinical symptoms in the postoperative period. Conclusion. Adequate restoration of the endothelial layer in patients with pelvic floor muscle incompetence and endothelial dysfunction reduces the likelihood of developing mesh-associated complications after the surgical stage of treatment.Irina A. LapinaYulia E. DobrokhotovaVladislav V. TaranovTatiana G. ChirvonPolina VolkovaAnastasia A. MalakhovaIP Berlin A.V. articlepelvic organ prolapsestress urinary incontinencemetabolic syndromeendothelial dysfunctionGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	pelvic organ prolapse stress urinary incontinence metabolic syndrome endothelial dysfunction Gynecology and obstetrics RG1-991
spellingShingle	pelvic organ prolapse stress urinary incontinence metabolic syndrome endothelial dysfunction Gynecology and obstetrics RG1-991 Irina A. Lapina Yulia E. Dobrokhotova Vladislav V. Taranov Tatiana G. Chirvon Polina Volkova Anastasia A. Malakhova Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
description	Background. Genital prolapse (GP) and stress urinary incontinence (SUI) are characterized by a failure of connective tissue skeleton of the pelvic floor structures, and there are many risk factors in their pathogenesis. Metabolic syndrome (MS), which includes obesity and abnormalities in the lipid and carbohydrate profile, contributes to the initiation of pelvic organ prolapse (POP) due to increased intra-abdominal pressure and the presence of comorbidities. Endothelial dysfunction associated with MS aggravates the existing metabolic disorders, resulting in the formation of a vicious circle and an increase in the likelihood of recurrence of genital prolapse symptoms and НМ during tension in the postoperative period. Aim. The search for rational algorithms for the comprehensive management of patients with POP and MS. Materials and methods. A comparative analysis of effectiveness of treatment with the use of surgical method or drugs which affect the metabolic profile in patients with GP and SUI was carried out. Results. Drugs which contribute the restoration of lipid and carbohydrate profiles, and microcirculatory vasculature normalization, attenuate negative effects of MS components on the integrity of pelvic floor structures. Comprehensive management of patients with POP and MS with surgical correction of GP and SUI, as well as the use of drugs affecting metabolism, is highly effective and predictive in regard to POP severity and the risk of recurrence of clinical symptoms in the postoperative period. Conclusion. Adequate restoration of the endothelial layer in patients with pelvic floor muscle incompetence and endothelial dysfunction reduces the likelihood of developing mesh-associated complications after the surgical stage of treatment.
format	article
author	Irina A. Lapina Yulia E. Dobrokhotova Vladislav V. Taranov Tatiana G. Chirvon Polina Volkova Anastasia A. Malakhova
author_facet	Irina A. Lapina Yulia E. Dobrokhotova Vladislav V. Taranov Tatiana G. Chirvon Polina Volkova Anastasia A. Malakhova
author_sort	Irina A. Lapina
title	Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
title_short	Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
title_full	Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
title_fullStr	Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
title_full_unstemmed	Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
title_sort	comprehensive management of patients with pelvis organ prolapse and metabolic syndrome
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/a53055b3f11c4834919fe1edfaa024e1
work_keys_str_mv	AT irinaalapina comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome AT yuliaedobrokhotova comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome AT vladislavvtaranov comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome AT tatianagchirvon comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome AT polinavolkova comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome AT anastasiaamalakhova comprehensivemanagementofpatientswithpelvisorganprolapseandmetabolicsyndrome
_version_	1718376755522174976

Comprehensive management of patients with pelvis organ prolapse and metabolic syndrome

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