Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.

Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Xie, Chenglong Luo, Chengguang Zhang, Rong Zhang, Jun Tang, Qinghua Nie, Li Ma, Xiaoxiang Hu, Ning Li, Yang Da, Xiquan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5305ca663c74f778275268b519aa218
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a5305ca663c74f778275268b519aa218
record_format	dspace
spelling	oai:doaj.org-article:a5305ca663c74f778275268b519aa2182021-11-18T07:28:04ZGenome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.1932-620310.1371/journal.pone.0030910https://doaj.org/article/a5305ca663c74f778275268b519aa2182012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22359555/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5-175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22-48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29-42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind to messenger ribonucleic acid (mRNA) of IGF1, FOXO1A and KPNA3. It was further indicated that the 1.5 Mb GGA1 region had the strongest effects on chicken growth during 22-42 d.Liang XieChenglong LuoChengguang ZhangRong ZhangJun TangQinghua NieLi MaXiaoxiang HuNing LiYang DaXiquan ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e30910 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Xie Chenglong Luo Chengguang Zhang Rong Zhang Jun Tang Qinghua Nie Li Ma Xiaoxiang Hu Ning Li Yang Da Xiquan Zhang Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
description	Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5-175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0-90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest significant effects for all growth traits in this study, including a SNP at 8.9 Kb upstream of FOXO1A for BW at 22-48 d and 70 d, a SNP at 1.9 Kb downstream of FOXO1A for WW, a SNP at 20.9 Kb downstream of ENSGALG00000022732 for ADG at 29-42 d, a SNP in INTS6 for BW at 90 d, and a SNP in KPNA3 for BMW and LMW. The 1.5 Mb KPNA3-FOXO1A region contained two microRNA genes that could bind to messenger ribonucleic acid (mRNA) of IGF1, FOXO1A and KPNA3. It was further indicated that the 1.5 Mb GGA1 region had the strongest effects on chicken growth during 22-42 d.
format	article
author	Liang Xie Chenglong Luo Chengguang Zhang Rong Zhang Jun Tang Qinghua Nie Li Ma Xiaoxiang Hu Ning Li Yang Da Xiquan Zhang
author_facet	Liang Xie Chenglong Luo Chengguang Zhang Rong Zhang Jun Tang Qinghua Nie Li Ma Xiaoxiang Hu Ning Li Yang Da Xiquan Zhang
author_sort	Liang Xie
title	Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
title_short	Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
title_full	Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
title_fullStr	Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
title_full_unstemmed	Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
title_sort	genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a5305ca663c74f778275268b519aa218
work_keys_str_mv	AT liangxie genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT chenglongluo genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT chengguangzhang genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT rongzhang genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT juntang genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT qinghuanie genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT lima genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT xiaoxianghu genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT ningli genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT yangda genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits AT xiquanzhang genomewideassociationstudyidentifiedanarrowchromosome1regionassociatedwithchickengrowthtraits
_version_	1718423428169465856

Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.

Ejemplares similares