Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine
RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation. With advances in RNA detection, various forms of RNA...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:a532342c643d4feaa39b67c93335d6512021-12-01T18:50:38ZRole of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine2296-634X10.3389/fcell.2021.767668https://doaj.org/article/a532342c643d4feaa39b67c93335d6512021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.767668/fullhttps://doaj.org/toc/2296-634XRNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation. With advances in RNA detection, various forms of RNA methylation can be found, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C). Emerging reports confirm that dysregulation of RNA methylation gives rise to a variety of human diseases, particularly hepatocellular carcinoma. We will summarize essential regulators of RNA methylation and biological functions of these modifications in coding and noncoding RNAs. In conclusion, we highlight complex molecular mechanisms of m6A, m5C, and m1A associated with hepatocellular carcinoma and hope this review might provide therapeutic potent of RNA methylation to clinical research.Yating XuYating XuYating XuYating XuMenggang ZhangMenggang ZhangMenggang ZhangMenggang ZhangQiyao ZhangQiyao ZhangQiyao ZhangQiyao ZhangXiao YuXiao YuXiao YuXiao YuZongzong SunYuting HeYuting HeYuting HeYuting HeWenzhi GuoWenzhi GuoWenzhi GuoWenzhi GuoFrontiers Media S.A.articlehepatocellular carcinomaRNA methylationM6Am5Cm1ABiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
hepatocellular carcinoma RNA methylation M6A m5C m1A Biology (General) QH301-705.5 |
| spellingShingle |
hepatocellular carcinoma RNA methylation M6A m5C m1A Biology (General) QH301-705.5 Yating Xu Yating Xu Yating Xu Yating Xu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Zongzong Sun Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| description |
RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation. With advances in RNA detection, various forms of RNA methylation can be found, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C). Emerging reports confirm that dysregulation of RNA methylation gives rise to a variety of human diseases, particularly hepatocellular carcinoma. We will summarize essential regulators of RNA methylation and biological functions of these modifications in coding and noncoding RNAs. In conclusion, we highlight complex molecular mechanisms of m6A, m5C, and m1A associated with hepatocellular carcinoma and hope this review might provide therapeutic potent of RNA methylation to clinical research. |
| format |
article |
| author |
Yating Xu Yating Xu Yating Xu Yating Xu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Zongzong Sun Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| author_facet |
Yating Xu Yating Xu Yating Xu Yating Xu Menggang Zhang Menggang Zhang Menggang Zhang Menggang Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Qiyao Zhang Xiao Yu Xiao Yu Xiao Yu Xiao Yu Zongzong Sun Yuting He Yuting He Yuting He Yuting He Wenzhi Guo Wenzhi Guo Wenzhi Guo Wenzhi Guo |
| author_sort |
Yating Xu |
| title |
Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| title_short |
Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| title_full |
Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| title_fullStr |
Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| title_full_unstemmed |
Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine |
| title_sort |
role of main rna methylation in hepatocellular carcinoma: n6-methyladenosine, 5-methylcytosine, and n1-methyladenosine |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/a532342c643d4feaa39b67c93335d651 |
| work_keys_str_mv |
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