Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy

Cisplatin is a widely used chemotherapeutic agent but its clinical use is often limited by nephrotoxicity. Autophagy is a lysosomal degradation pathway that removes protein aggregates and damaged or dysfunctional cellular organelles for maintaining cell homeostasis. Upon cisplatin exposure, autophag...

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Autores principales:	Xiaoru Hu, Zhengwei Ma, Lu Wen, Siyao Li, Zheng Dong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cisplatin autophagy acute kidney injury chronic kidney disease nephrotoxicity cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a5335d482e864e4583dc65ee52e17546
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spelling	oai:doaj.org-article:a5335d482e864e4583dc65ee52e175462021-11-25T17:01:39ZAutophagy in Cisplatin Nephrotoxicity during Cancer Therapy10.3390/cancers132256182072-6694https://doaj.org/article/a5335d482e864e4583dc65ee52e175462021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5618https://doaj.org/toc/2072-6694Cisplatin is a widely used chemotherapeutic agent but its clinical use is often limited by nephrotoxicity. Autophagy is a lysosomal degradation pathway that removes protein aggregates and damaged or dysfunctional cellular organelles for maintaining cell homeostasis. Upon cisplatin exposure, autophagy is rapidly activated in renal tubule cells to protect against acute cisplatin nephrotoxicity. Mechanistically, the protective effect is mainly related to the clearance of damaged mitochondria via mitophagy. The role and regulation of autophagy in chronic kidney problems after cisplatin treatment are currently unclear, despite the significance of research in this area. In cancers, autophagy may prevent tumorigenesis, but autophagy may reduce the efficacy of chemotherapy by protecting cancer cells. Future research should focus on developing drugs that enhance the anti-tumor effects of cisplatin while protecting kidneys during cisplatin chemotherapy.Xiaoru HuZhengwei MaLu WenSiyao LiZheng DongMDPI AGarticlecisplatinautophagyacute kidney injurychronic kidney diseasenephrotoxicitycancer therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5618, p 5618 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cisplatin autophagy acute kidney injury chronic kidney disease nephrotoxicity cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cisplatin autophagy acute kidney injury chronic kidney disease nephrotoxicity cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiaoru Hu Zhengwei Ma Lu Wen Siyao Li Zheng Dong Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
description	Cisplatin is a widely used chemotherapeutic agent but its clinical use is often limited by nephrotoxicity. Autophagy is a lysosomal degradation pathway that removes protein aggregates and damaged or dysfunctional cellular organelles for maintaining cell homeostasis. Upon cisplatin exposure, autophagy is rapidly activated in renal tubule cells to protect against acute cisplatin nephrotoxicity. Mechanistically, the protective effect is mainly related to the clearance of damaged mitochondria via mitophagy. The role and regulation of autophagy in chronic kidney problems after cisplatin treatment are currently unclear, despite the significance of research in this area. In cancers, autophagy may prevent tumorigenesis, but autophagy may reduce the efficacy of chemotherapy by protecting cancer cells. Future research should focus on developing drugs that enhance the anti-tumor effects of cisplatin while protecting kidneys during cisplatin chemotherapy.
format	article
author	Xiaoru Hu Zhengwei Ma Lu Wen Siyao Li Zheng Dong
author_facet	Xiaoru Hu Zhengwei Ma Lu Wen Siyao Li Zheng Dong
author_sort	Xiaoru Hu
title	Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
title_short	Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
title_full	Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
title_fullStr	Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
title_full_unstemmed	Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy
title_sort	autophagy in cisplatin nephrotoxicity during cancer therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a5335d482e864e4583dc65ee52e17546
work_keys_str_mv	AT xiaoruhu autophagyincisplatinnephrotoxicityduringcancertherapy AT zhengweima autophagyincisplatinnephrotoxicityduringcancertherapy AT luwen autophagyincisplatinnephrotoxicityduringcancertherapy AT siyaoli autophagyincisplatinnephrotoxicityduringcancertherapy AT zhengdong autophagyincisplatinnephrotoxicityduringcancertherapy
_version_	1718412793980387328

Autophagy in Cisplatin Nephrotoxicity during Cancer Therapy

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