Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer

Triple-negative breast cancers are heterogeneous, poorly prognostic, and metastatic malignancies that result in a high risk of death for patients. Targeted therapy for triple-negative breast cancer has been extremely challenging due to the lack of expression of estrogen receptor, progesterone recept...

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Autores principales:	Wenjie Zhao, Jinhua Liu, Yaqun Li, Zichao Chen, Dongmei Qi, Zhen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	triple-negative breast cancer traditional Chinese medicine herbal remedies active ingredients tumor immunity anti-tumor Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a534846f23ce4e4e9c63b82abe30376a
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spelling	oai:doaj.org-article:a534846f23ce4e4e9c63b82abe30376a2021-12-03T07:05:04ZImmune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer1663-981210.3389/fphar.2021.731741https://doaj.org/article/a534846f23ce4e4e9c63b82abe30376a2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.731741/fullhttps://doaj.org/toc/1663-9812Triple-negative breast cancers are heterogeneous, poorly prognostic, and metastatic malignancies that result in a high risk of death for patients. Targeted therapy for triple-negative breast cancer has been extremely challenging due to the lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Clinical treatment regimens for triple-negative breast cancer are often based on paclitaxel and platinum drugs, but drug resistance and side effects from the drugs frequently lead to treatment failure, thus requiring the development of new therapeutic platforms. In recent years, research on traditional Chinese medicine in modulating the immune function of the body has shown that it has the potential to be an effective treatment option against triple-negative breast cancer. Active components of herbal medicines such as alkaloids, flavonoids, polyphenols, saponins, and polysaccharides have been shown to inhibit cancer cell proliferation and metastasis by activating inflammatory immune responses and can modulate tumor-related signaling pathways to further inhibit the invasion of triple-negative breast cancer. This paper reviews the immunomodulatory mechanisms of different herbal active ingredients against triple-negative breast cancer and provides an outlook on the challenges and directions of development for the treatment of triple-negative breast cancer with herbal active ingredients.Wenjie ZhaoWenjie ZhaoJinhua LiuYaqun LiZichao ChenZichao ChenDongmei QiDongmei QiZhen ZhangFrontiers Media S.A.articletriple-negative breast cancertraditional Chinese medicineherbal remedies active ingredientstumor immunityanti-tumorTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	triple-negative breast cancer traditional Chinese medicine herbal remedies active ingredients tumor immunity anti-tumor Therapeutics. Pharmacology RM1-950
spellingShingle	triple-negative breast cancer traditional Chinese medicine herbal remedies active ingredients tumor immunity anti-tumor Therapeutics. Pharmacology RM1-950 Wenjie Zhao Wenjie Zhao Jinhua Liu Yaqun Li Zichao Chen Zichao Chen Dongmei Qi Dongmei Qi Zhen Zhang Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
description	Triple-negative breast cancers are heterogeneous, poorly prognostic, and metastatic malignancies that result in a high risk of death for patients. Targeted therapy for triple-negative breast cancer has been extremely challenging due to the lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Clinical treatment regimens for triple-negative breast cancer are often based on paclitaxel and platinum drugs, but drug resistance and side effects from the drugs frequently lead to treatment failure, thus requiring the development of new therapeutic platforms. In recent years, research on traditional Chinese medicine in modulating the immune function of the body has shown that it has the potential to be an effective treatment option against triple-negative breast cancer. Active components of herbal medicines such as alkaloids, flavonoids, polyphenols, saponins, and polysaccharides have been shown to inhibit cancer cell proliferation and metastasis by activating inflammatory immune responses and can modulate tumor-related signaling pathways to further inhibit the invasion of triple-negative breast cancer. This paper reviews the immunomodulatory mechanisms of different herbal active ingredients against triple-negative breast cancer and provides an outlook on the challenges and directions of development for the treatment of triple-negative breast cancer with herbal active ingredients.
format	article
author	Wenjie Zhao Wenjie Zhao Jinhua Liu Yaqun Li Zichao Chen Zichao Chen Dongmei Qi Dongmei Qi Zhen Zhang
author_facet	Wenjie Zhao Wenjie Zhao Jinhua Liu Yaqun Li Zichao Chen Zichao Chen Dongmei Qi Dongmei Qi Zhen Zhang
author_sort	Wenjie Zhao
title	Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
title_short	Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
title_full	Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
title_fullStr	Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
title_full_unstemmed	Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer
title_sort	immune effect of active components of traditional chinese medicine on triple-negative breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a534846f23ce4e4e9c63b82abe30376a
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Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer

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