Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity

Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.

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Autores principales: Wen Fong Ooi, Manjie Xing, Chang Xu, Xiaosai Yao, Muhammad Khairul Ramlee, Mei Chee Lim, Fan Cao, Kevin Lim, Deepak Babu, Lai-Fong Poon, Joyce Lin Suling, Aditi Qamra, Astrid Irwanto, James Qu Zhengzhong, Tannistha Nandi, Ai Ping Lee-Lim, Yang Sun Chan, Su Ting Tay, Ming Hui Lee, James O. J. Davies, Wai Keong Wong, Khee Chee Soo, Weng Hoong Chan, Hock Soo Ong, Pierce Chow, Chow Yin Wong, Sun Young Rha, Jianjun Liu, Axel M. Hillmer, Jim R. Hughes, Steve Rozen, Bin Tean Teh, Melissa Jane Fullwood, Shang Li, Patrick Tan
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a537b19ccbb94c08a4be48239ebf76e6
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spelling oai:doaj.org-article:a537b19ccbb94c08a4be48239ebf76e62021-12-02T14:39:11ZEpigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity10.1038/ncomms129832041-1723https://doaj.org/article/a537b19ccbb94c08a4be48239ebf76e62016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12983https://doaj.org/toc/2041-1723Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.Wen Fong OoiManjie XingChang XuXiaosai YaoMuhammad Khairul RamleeMei Chee LimFan CaoKevin LimDeepak BabuLai-Fong PoonJoyce Lin SulingAditi QamraAstrid IrwantoJames Qu ZhengzhongTannistha NandiAi Ping Lee-LimYang Sun ChanSu Ting TayMing Hui LeeJames O. J. DaviesWai Keong WongKhee Chee SooWeng Hoong ChanHock Soo OngPierce ChowChow Yin WongSun Young RhaJianjun LiuAxel M. HillmerJim R. HughesSteve RozenBin Tean TehMelissa Jane FullwoodShang LiPatrick TanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wen Fong Ooi
Manjie Xing
Chang Xu
Xiaosai Yao
Muhammad Khairul Ramlee
Mei Chee Lim
Fan Cao
Kevin Lim
Deepak Babu
Lai-Fong Poon
Joyce Lin Suling
Aditi Qamra
Astrid Irwanto
James Qu Zhengzhong
Tannistha Nandi
Ai Ping Lee-Lim
Yang Sun Chan
Su Ting Tay
Ming Hui Lee
James O. J. Davies
Wai Keong Wong
Khee Chee Soo
Weng Hoong Chan
Hock Soo Ong
Pierce Chow
Chow Yin Wong
Sun Young Rha
Jianjun Liu
Axel M. Hillmer
Jim R. Hughes
Steve Rozen
Bin Tean Teh
Melissa Jane Fullwood
Shang Li
Patrick Tan
Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
description Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations.
format article
author Wen Fong Ooi
Manjie Xing
Chang Xu
Xiaosai Yao
Muhammad Khairul Ramlee
Mei Chee Lim
Fan Cao
Kevin Lim
Deepak Babu
Lai-Fong Poon
Joyce Lin Suling
Aditi Qamra
Astrid Irwanto
James Qu Zhengzhong
Tannistha Nandi
Ai Ping Lee-Lim
Yang Sun Chan
Su Ting Tay
Ming Hui Lee
James O. J. Davies
Wai Keong Wong
Khee Chee Soo
Weng Hoong Chan
Hock Soo Ong
Pierce Chow
Chow Yin Wong
Sun Young Rha
Jianjun Liu
Axel M. Hillmer
Jim R. Hughes
Steve Rozen
Bin Tean Teh
Melissa Jane Fullwood
Shang Li
Patrick Tan
author_facet Wen Fong Ooi
Manjie Xing
Chang Xu
Xiaosai Yao
Muhammad Khairul Ramlee
Mei Chee Lim
Fan Cao
Kevin Lim
Deepak Babu
Lai-Fong Poon
Joyce Lin Suling
Aditi Qamra
Astrid Irwanto
James Qu Zhengzhong
Tannistha Nandi
Ai Ping Lee-Lim
Yang Sun Chan
Su Ting Tay
Ming Hui Lee
James O. J. Davies
Wai Keong Wong
Khee Chee Soo
Weng Hoong Chan
Hock Soo Ong
Pierce Chow
Chow Yin Wong
Sun Young Rha
Jianjun Liu
Axel M. Hillmer
Jim R. Hughes
Steve Rozen
Bin Tean Teh
Melissa Jane Fullwood
Shang Li
Patrick Tan
author_sort Wen Fong Ooi
title Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
title_short Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
title_full Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
title_fullStr Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
title_full_unstemmed Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
title_sort epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/a537b19ccbb94c08a4be48239ebf76e6
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