Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.
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Nature Portfolio
2017
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oai:doaj.org-article:a53af0caadf64c108081ce0c70f541ee2021-12-02T13:57:33ZTherapeutic efficacy of a respiratory syncytial virus fusion inhibitor10.1038/s41467-017-00170-x2041-1723https://doaj.org/article/a53af0caadf64c108081ce0c70f541ee2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00170-xhttps://doaj.org/toc/2041-1723Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.Dirk RoymansSarhad S AlnajjarMichael B BattlesPanchan SitthicharoenchaiPolina Furmanova-HollensteinPeter RigauxJoke Van den BergLeen KwantenMarcia Van GinderenNick VerheyenLuc VranckxSteffen JaenschEric ArnoultRichard VoorzaatJack M. GallupAlejandro Larios-MoraMarjolein CrabbeDymphy HuntjensPierre RaboissonJohannes P. LangedijkMark R. AckermannJason S McLellanSandrine VendevilleAnil KoulNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dirk Roymans Sarhad S Alnajjar Michael B Battles Panchan Sitthicharoenchai Polina Furmanova-Hollenstein Peter Rigaux Joke Van den Berg Leen Kwanten Marcia Van Ginderen Nick Verheyen Luc Vranckx Steffen Jaensch Eric Arnoult Richard Voorzaat Jack M. Gallup Alejandro Larios-Mora Marjolein Crabbe Dymphy Huntjens Pierre Raboisson Johannes P. Langedijk Mark R. Ackermann Jason S McLellan Sandrine Vendeville Anil Koul Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| description |
Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs. |
| format |
article |
| author |
Dirk Roymans Sarhad S Alnajjar Michael B Battles Panchan Sitthicharoenchai Polina Furmanova-Hollenstein Peter Rigaux Joke Van den Berg Leen Kwanten Marcia Van Ginderen Nick Verheyen Luc Vranckx Steffen Jaensch Eric Arnoult Richard Voorzaat Jack M. Gallup Alejandro Larios-Mora Marjolein Crabbe Dymphy Huntjens Pierre Raboisson Johannes P. Langedijk Mark R. Ackermann Jason S McLellan Sandrine Vendeville Anil Koul |
| author_facet |
Dirk Roymans Sarhad S Alnajjar Michael B Battles Panchan Sitthicharoenchai Polina Furmanova-Hollenstein Peter Rigaux Joke Van den Berg Leen Kwanten Marcia Van Ginderen Nick Verheyen Luc Vranckx Steffen Jaensch Eric Arnoult Richard Voorzaat Jack M. Gallup Alejandro Larios-Mora Marjolein Crabbe Dymphy Huntjens Pierre Raboisson Johannes P. Langedijk Mark R. Ackermann Jason S McLellan Sandrine Vendeville Anil Koul |
| author_sort |
Dirk Roymans |
| title |
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| title_short |
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| title_full |
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| title_fullStr |
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| title_full_unstemmed |
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| title_sort |
therapeutic efficacy of a respiratory syncytial virus fusion inhibitor |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a53af0caadf64c108081ce0c70f541ee |
| work_keys_str_mv |
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| _version_ |
1718392338432131072 |