Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder

Masaki Nishida,1 Yusaku Nakashima,2 Toru Nishikawa11Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo, 2Medical Technology Research Laboratory, Research and Development Division, Medical Business Uni...

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Autores principales:	Nishida M, Nakashima Y, Nishikawa T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	depression memory consolidation motor skill polysomnography sleep spindle thalamo-cortical network Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/a5416aa81d114a4f9f385a3569fc53bd
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spelling	oai:doaj.org-article:a5416aa81d114a4f9f385a3569fc53bd2021-12-02T09:00:06ZSlow sleep spindle and procedural memory consolidation in patients with major depressive disorder1179-1608https://doaj.org/article/a5416aa81d114a4f9f385a3569fc53bd2016-01-01T00:00:00Zhttps://www.dovepress.com/slow-sleep-spindle-and-procedural-memory-consolidation-in-patients-wit-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Masaki Nishida,1 Yusaku Nakashima,2 Toru Nishikawa11Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo, 2Medical Technology Research Laboratory, Research and Development Division, Medical Business Unit, Sony Corporation, Tokyo, JapanIntroduction: Evidence has accumulated, which indicates that, in healthy individuals, sleep enhances procedural memory consolidation, and that sleep spindle activity modulates this process. However, whether sleep-dependent procedural memory consolidation occurs in patients medicated for major depressive disorder remains unclear, as are the pharmacological and physiological mechanisms that underlie this process.Methods: Healthy control participants (n=17) and patients medicated for major depressive disorder (n=11) were recruited and subjected to a finger-tapping motor sequence test (MST; nondominant hand) paradigm to compare the averaged scores of different learning phases (presleep, postsleep, and overnight improvement). Participants' brain activity was recorded during sleep with 16 electroencephalography channels (between MSTs). Sleep scoring and frequency analyses were performed on the electroencephalography data. Additionally, we evaluated sleep spindle activity, which divided the spindles into fast-frequency spindle activity (12.5–16 Hz) and slow-frequency spindle activity (10.5–12.5 Hz).Result: Sleep-dependent motor memory consolidation in patients with depression was impaired in comparison with that in control participants. In patients with depression, age correlated negatively with overnight improvement. The duration of slow-wave sleep correlated with the magnitude of motor memory consolidation in patients with depression, but not in healthy controls. Slow-frequency spindle activity was associated with reduction in the magnitude of motor memory consolidation in both groups.Conclusion: Because the changes in slow-frequency spindle activity affected the thalamocortical network dysfunction in patients medicated for depression, dysregulated spindle generation may impair sleep-dependent memory consolidation. Our findings may help to elucidate the cognitive deficits that occur in patients with major depression both in the waking state and during sleep.Keywords: depression, memory consolidation, motor skill, polysomnography, sleep spindle, thalamocortical networkNishida MNakashima YNishikawa TDove Medical Pressarticledepressionmemory consolidationmotor skillpolysomnographysleep spindlethalamo-cortical networkPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2016, Iss Issue 1, Pp 63-72 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression memory consolidation motor skill polysomnography sleep spindle thalamo-cortical network Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	depression memory consolidation motor skill polysomnography sleep spindle thalamo-cortical network Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Nishida M Nakashima Y Nishikawa T Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
description	Masaki Nishida,1 Yusaku Nakashima,2 Toru Nishikawa11Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo, 2Medical Technology Research Laboratory, Research and Development Division, Medical Business Unit, Sony Corporation, Tokyo, JapanIntroduction: Evidence has accumulated, which indicates that, in healthy individuals, sleep enhances procedural memory consolidation, and that sleep spindle activity modulates this process. However, whether sleep-dependent procedural memory consolidation occurs in patients medicated for major depressive disorder remains unclear, as are the pharmacological and physiological mechanisms that underlie this process.Methods: Healthy control participants (n=17) and patients medicated for major depressive disorder (n=11) were recruited and subjected to a finger-tapping motor sequence test (MST; nondominant hand) paradigm to compare the averaged scores of different learning phases (presleep, postsleep, and overnight improvement). Participants' brain activity was recorded during sleep with 16 electroencephalography channels (between MSTs). Sleep scoring and frequency analyses were performed on the electroencephalography data. Additionally, we evaluated sleep spindle activity, which divided the spindles into fast-frequency spindle activity (12.5–16 Hz) and slow-frequency spindle activity (10.5–12.5 Hz).Result: Sleep-dependent motor memory consolidation in patients with depression was impaired in comparison with that in control participants. In patients with depression, age correlated negatively with overnight improvement. The duration of slow-wave sleep correlated with the magnitude of motor memory consolidation in patients with depression, but not in healthy controls. Slow-frequency spindle activity was associated with reduction in the magnitude of motor memory consolidation in both groups.Conclusion: Because the changes in slow-frequency spindle activity affected the thalamocortical network dysfunction in patients medicated for depression, dysregulated spindle generation may impair sleep-dependent memory consolidation. Our findings may help to elucidate the cognitive deficits that occur in patients with major depression both in the waking state and during sleep.Keywords: depression, memory consolidation, motor skill, polysomnography, sleep spindle, thalamocortical network
format	article
author	Nishida M Nakashima Y Nishikawa T
author_facet	Nishida M Nakashima Y Nishikawa T
author_sort	Nishida M
title	Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
title_short	Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
title_full	Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
title_fullStr	Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
title_full_unstemmed	Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
title_sort	slow sleep spindle and procedural memory consolidation in patients with major depressive disorder
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a5416aa81d114a4f9f385a3569fc53bd
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Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder

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