Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy

Objectives: Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Steve Harkaeh, Yousef Qari, Hanaa Tashkandi, Mohammed Almuhayawi, Saber H. Saber, Emad aljahdali, Nagla El-Shitany, Soad Shaker, Filipa Lucas, Turki Alamri, Soad Al-Jaouni, Shaker Mousa
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cisplatin Thymoquinone Nephrotoxicity Ehrlich Antioxidant Anti-inflammatory Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/a544168d522d4889b4e1b833fc72f442
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a544168d522d4889b4e1b833fc72f442
record_format	dspace
spelling	oai:doaj.org-article:a544168d522d4889b4e1b833fc72f4422021-12-02T04:59:30ZThymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy1018-364710.1016/j.jksus.2021.101675https://doaj.org/article/a544168d522d4889b4e1b833fc72f4422022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003372https://doaj.org/toc/1018-3647Objectives: Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model. Methods: Four treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP + NP THY. Results: The results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn’t hinder the antitumor activity of CISP as shown by tumour weight and histological examination data. Conclusions: In conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy.Steve HarkaehYousef QariHanaa TashkandiMohammed AlmuhayawiSaber H. SaberEmad aljahdaliNagla El-ShitanySoad ShakerFilipa LucasTurki AlamriSoad Al-JaouniShaker MousaElsevierarticleCisplatinThymoquinoneNephrotoxicityEhrlichAntioxidantAnti-inflammatoryScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101675- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin Thymoquinone Nephrotoxicity Ehrlich Antioxidant Anti-inflammatory Science (General) Q1-390
spellingShingle	Cisplatin Thymoquinone Nephrotoxicity Ehrlich Antioxidant Anti-inflammatory Science (General) Q1-390 Steve Harkaeh Yousef Qari Hanaa Tashkandi Mohammed Almuhayawi Saber H. Saber Emad aljahdali Nagla El-Shitany Soad Shaker Filipa Lucas Turki Alamri Soad Al-Jaouni Shaker Mousa Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
description	Objectives: Cisplatin (CISP) is an effective chemotherapy used in the treatment of various types of cancer, but it causes nephrotoxicity and other adverse effects. Thymoquinone (THY) is an effective anti-inflammatory and antioxidant compound, which might protects against many chemotherapies associated toxicities. However, THY applications are hindered by its poor solubility and low bioavailability. This study evaluated the efficacy of a novel nanoparticle (NP) encapsulting THY to overcome its poor solubility, enhance its bioavilability, efficacy for the protection against CISP-induced nephrotoxicity in an Ehrlich solid carcinoma (ESC) mice model. Methods: Four treatment groups were included: 1) control, 2) tumour, 3) CISP, and 4) CISP + NP THY. Results: The results showed that NP THY was effective in preventing CISP-induced kidney toxicity in ESC mice and improved its function and pathology. NP THY effectively ameliorated CISP-induced oxidative stress conditions in the kidney tissue via increasing the levels of antioxidants both non-enzymatic (GSH) and enzymatic (SOD and CAT). NP THY, also, significantly reduced CISP-induced kidney inflammation by reducing TNF-α, IL-1β, and NF-kB levels. NP THY didn’t hinder the antitumor activity of CISP as shown by tumour weight and histological examination data. Conclusions: In conclusion, NP THY could be an adjuvant therapy to CISP cancer treatment to prevent associated nephrotoxicity and other adverse effects without compromising CISP antitumor efficacy.
format	article
author	Steve Harkaeh Yousef Qari Hanaa Tashkandi Mohammed Almuhayawi Saber H. Saber Emad aljahdali Nagla El-Shitany Soad Shaker Filipa Lucas Turki Alamri Soad Al-Jaouni Shaker Mousa
author_facet	Steve Harkaeh Yousef Qari Hanaa Tashkandi Mohammed Almuhayawi Saber H. Saber Emad aljahdali Nagla El-Shitany Soad Shaker Filipa Lucas Turki Alamri Soad Al-Jaouni Shaker Mousa
author_sort	Steve Harkaeh
title	Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
title_short	Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
title_full	Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
title_fullStr	Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
title_full_unstemmed	Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
title_sort	thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/a544168d522d4889b4e1b833fc72f442
work_keys_str_mv	AT steveharkaeh thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT yousefqari thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT hanaatashkandi thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT mohammedalmuhayawi thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT saberhsaber thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT emadaljahdali thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT naglaelshitany thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT soadshaker thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT filipalucas thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT turkialamri thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT soadaljaouni thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy AT shakermousa thymoquinonenanoparticlesprotectagainstcisplatininducednephrotoxicityinehrlichcarcinomamodelwithoutcompromisingcisplatinanticancerefficacy
_version_	1718400908434341888

Thymoquinone nanoparticles protect against cisplatin-induced nephrotoxicity in Ehrlich carcinoma model without compromising cisplatin anti-cancer efficacy

Ejemplares similares