Effect of interleukin 6 deficiency on renal interstitial fibrosis.

Our recent studies have shown that bone marrow-derived fibroblast precursors contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment and activation of bone marrow-derived fibroblast precursors are incompletely understood. We found...

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Autores principales:	Jun Yang, Jiyuan Chen, Jingyin Yan, Liping Zhang, Gang Chen, Liqun He, Yanlin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a54433ccd13d4f948b95f97bb2625ee6
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spelling	oai:doaj.org-article:a54433ccd13d4f948b95f97bb2625ee62021-11-18T08:04:37ZEffect of interleukin 6 deficiency on renal interstitial fibrosis.1932-620310.1371/journal.pone.0052415https://doaj.org/article/a54433ccd13d4f948b95f97bb2625ee62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272241/?tool=EBIhttps://doaj.org/toc/1932-6203Our recent studies have shown that bone marrow-derived fibroblast precursors contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment and activation of bone marrow-derived fibroblast precursors are incompletely understood. We found that interleukin 6 was induced in the kidney in a murine model of renal fibrosis induced by unilateral ureteral obstruction. Therefore, we investigated if interleukin 6 play a role in the recruitment and maturation of bone marrow-derived fibroblast precursors in the kidney during the development of renal fibrosis. Wild-type and interleukin 6 knockout mice were subjected to unilateral obstructive injury for up to two weeks. Interleukin 6 knockout mice accumulated similar number of bone marrow-derived fibroblast precursors and myofibroblasts in the kidney in response to obstructive injury compared to wild-type mice. Furthermore, IL-6 knockout mice expressed comparable α-SMA in the obstructed kidney compared to wild-type mice. Moreover, targeted disruption of Interleukin 6 did not affect gene expression of profibrotic chemokine and cytokines in the obstructed kidney. Finally, there were no significant differences in renal interstitial fibrosis or expression of extracellular matrix proteins between wild-type and interleukin 6 knockout mice following obstructive injury. Our results indicate that interleukin 6 does not play a significant role in the recruitment of bone marrow-derived fibroblast precursors and the development of renal fibrosis.Jun YangJiyuan ChenJingyin YanLiping ZhangGang ChenLiqun HeYanlin WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52415 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Yang Jiyuan Chen Jingyin Yan Liping Zhang Gang Chen Liqun He Yanlin Wang Effect of interleukin 6 deficiency on renal interstitial fibrosis.
description	Our recent studies have shown that bone marrow-derived fibroblast precursors contribute significantly to the pathogenesis of renal fibrosis. However, the molecular mechanisms underlying the recruitment and activation of bone marrow-derived fibroblast precursors are incompletely understood. We found that interleukin 6 was induced in the kidney in a murine model of renal fibrosis induced by unilateral ureteral obstruction. Therefore, we investigated if interleukin 6 play a role in the recruitment and maturation of bone marrow-derived fibroblast precursors in the kidney during the development of renal fibrosis. Wild-type and interleukin 6 knockout mice were subjected to unilateral obstructive injury for up to two weeks. Interleukin 6 knockout mice accumulated similar number of bone marrow-derived fibroblast precursors and myofibroblasts in the kidney in response to obstructive injury compared to wild-type mice. Furthermore, IL-6 knockout mice expressed comparable α-SMA in the obstructed kidney compared to wild-type mice. Moreover, targeted disruption of Interleukin 6 did not affect gene expression of profibrotic chemokine and cytokines in the obstructed kidney. Finally, there were no significant differences in renal interstitial fibrosis or expression of extracellular matrix proteins between wild-type and interleukin 6 knockout mice following obstructive injury. Our results indicate that interleukin 6 does not play a significant role in the recruitment of bone marrow-derived fibroblast precursors and the development of renal fibrosis.
format	article
author	Jun Yang Jiyuan Chen Jingyin Yan Liping Zhang Gang Chen Liqun He Yanlin Wang
author_facet	Jun Yang Jiyuan Chen Jingyin Yan Liping Zhang Gang Chen Liqun He Yanlin Wang
author_sort	Jun Yang
title	Effect of interleukin 6 deficiency on renal interstitial fibrosis.
title_short	Effect of interleukin 6 deficiency on renal interstitial fibrosis.
title_full	Effect of interleukin 6 deficiency on renal interstitial fibrosis.
title_fullStr	Effect of interleukin 6 deficiency on renal interstitial fibrosis.
title_full_unstemmed	Effect of interleukin 6 deficiency on renal interstitial fibrosis.
title_sort	effect of interleukin 6 deficiency on renal interstitial fibrosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a54433ccd13d4f948b95f97bb2625ee6
work_keys_str_mv	AT junyang effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT jiyuanchen effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT jingyinyan effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT lipingzhang effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT gangchen effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT liqunhe effectofinterleukin6deficiencyonrenalinterstitialfibrosis AT yanlinwang effectofinterleukin6deficiencyonrenalinterstitialfibrosis
_version_	1718422248039120896

Effect of interleukin 6 deficiency on renal interstitial fibrosis.

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