Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Animals can adapt their body size to changing environments (e.g., temperature) but the underlying molecular mechanisms are unknown. Here, the authors show that temperature and the genetic factors insulin-like peptide receptor and FoxO determine size in Hydra via the conserved pathways (Wnt/TGF-β).

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Autores principales:	Benedikt M. Mortzfeld, Jan Taubenheim, Alexander V. Klimovich, Sebastian Fraune, Philip Rosenstiel, Thomas C. G. Bosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a54475c745684a26b3831a7fe24847f4
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spelling	oai:doaj.org-article:a54475c745684a26b3831a7fe24847f42021-12-02T16:58:26ZTemperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways10.1038/s41467-019-11136-62041-1723https://doaj.org/article/a54475c745684a26b3831a7fe24847f42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11136-6https://doaj.org/toc/2041-1723Animals can adapt their body size to changing environments (e.g., temperature) but the underlying molecular mechanisms are unknown. Here, the authors show that temperature and the genetic factors insulin-like peptide receptor and FoxO determine size in Hydra via the conserved pathways (Wnt/TGF-β).Benedikt M. MortzfeldJan TaubenheimAlexander V. KlimovichSebastian FraunePhilip RosenstielThomas C. G. BoschNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benedikt M. Mortzfeld Jan Taubenheim Alexander V. Klimovich Sebastian Fraune Philip Rosenstiel Thomas C. G. Bosch Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
description	Animals can adapt their body size to changing environments (e.g., temperature) but the underlying molecular mechanisms are unknown. Here, the authors show that temperature and the genetic factors insulin-like peptide receptor and FoxO determine size in Hydra via the conserved pathways (Wnt/TGF-β).
format	article
author	Benedikt M. Mortzfeld Jan Taubenheim Alexander V. Klimovich Sebastian Fraune Philip Rosenstiel Thomas C. G. Bosch
author_facet	Benedikt M. Mortzfeld Jan Taubenheim Alexander V. Klimovich Sebastian Fraune Philip Rosenstiel Thomas C. G. Bosch
author_sort	Benedikt M. Mortzfeld
title	Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
title_short	Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
title_full	Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
title_fullStr	Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
title_full_unstemmed	Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
title_sort	temperature and insulin signaling regulate body size in hydra by the wnt and tgf-beta pathways
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a54475c745684a26b3831a7fe24847f4
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Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

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