Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study,...

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Autores principales:	Inna V. Fadeeva, Elena S. Trofimchuk, Anna A. Forysenkova, Abdulrahman I. Ahmed, Oleg I. Gnezdilov, Galina A. Davydova, Svetlana G. Kozlova, Aurora Antoniac, Julietta V. Rau
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyvinylpyrrolidone sodium alginate hydroxyapatite composite films Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/a546ccaae4d141898acf61ea8837cd01
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spelling	oai:doaj.org-article:a546ccaae4d141898acf61ea8837cd012021-11-25T18:49:07ZComposite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications10.3390/polym132239892073-4360https://doaj.org/article/a546ccaae4d141898acf61ea8837cd012021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3989https://doaj.org/toc/2073-4360Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymer PVP-SA blend. The developed composite hydrogel films are recommended for such applications, such as membranes in osteoplastic surgery and wound dressing.Inna V. FadeevaElena S. TrofimchukAnna A. ForysenkovaAbdulrahman I. AhmedOleg I. GnezdilovGalina A. DavydovaSvetlana G. KozlovaAurora AntoniacJulietta V. RauMDPI AGarticlepolyvinylpyrrolidonesodium alginatehydroxyapatitecomposite filmsOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3989, p 3989 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyvinylpyrrolidone sodium alginate hydroxyapatite composite films Organic chemistry QD241-441
spellingShingle	polyvinylpyrrolidone sodium alginate hydroxyapatite composite films Organic chemistry QD241-441 Inna V. Fadeeva Elena S. Trofimchuk Anna A. Forysenkova Abdulrahman I. Ahmed Oleg I. Gnezdilov Galina A. Davydova Svetlana G. Kozlova Aurora Antoniac Julietta V. Rau Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
description	Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymer PVP-SA blend. The developed composite hydrogel films are recommended for such applications, such as membranes in osteoplastic surgery and wound dressing.
format	article
author	Inna V. Fadeeva Elena S. Trofimchuk Anna A. Forysenkova Abdulrahman I. Ahmed Oleg I. Gnezdilov Galina A. Davydova Svetlana G. Kozlova Aurora Antoniac Julietta V. Rau
author_facet	Inna V. Fadeeva Elena S. Trofimchuk Anna A. Forysenkova Abdulrahman I. Ahmed Oleg I. Gnezdilov Galina A. Davydova Svetlana G. Kozlova Aurora Antoniac Julietta V. Rau
author_sort	Inna V. Fadeeva
title	Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
title_short	Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
title_full	Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
title_fullStr	Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
title_full_unstemmed	Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications
title_sort	composite polyvinylpyrrolidone–sodium alginate—hydroxyapatite hydrogel films for bone repair and wound dressings applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a546ccaae4d141898acf61ea8837cd01
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Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

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