Angiogenesis in Chronic Inflammatory Skin Disorders

Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β,...

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Autores principales:	Hyun Ji Lee, Yong Jun Hong, Miri Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	angiogenesis psoriasis atopic dermatitis rosacea chronic urticaria hidradenitis suppurativa Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a54d6de4fa0f46f786c3b5dedfb49e17
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spelling	oai:doaj.org-article:a54d6de4fa0f46f786c3b5dedfb49e172021-11-11T17:26:04ZAngiogenesis in Chronic Inflammatory Skin Disorders10.3390/ijms2221120351422-00671661-6596https://doaj.org/article/a54d6de4fa0f46f786c3b5dedfb49e172021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12035https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.Hyun Ji LeeYong Jun HongMiri KimMDPI AGarticleangiogenesispsoriasisatopic dermatitisrosaceachronic urticariahidradenitis suppurativaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12035, p 12035 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiogenesis psoriasis atopic dermatitis rosacea chronic urticaria hidradenitis suppurativa Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	angiogenesis psoriasis atopic dermatitis rosacea chronic urticaria hidradenitis suppurativa Biology (General) QH301-705.5 Chemistry QD1-999 Hyun Ji Lee Yong Jun Hong Miri Kim Angiogenesis in Chronic Inflammatory Skin Disorders
description	Angiogenesis, the growth of new blood vessels from preexisting vessels, is associated with inflammation in various pathological conditions. Well-known angiogenetic factors include vascular endothelial growth factor (VEGF), angiopoietins, platelet-derived growth factor, transforming growth factor-β, and basic fibroblast growth factor. Yes-associated protein 1 (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) have recently been added to an important angiogenic factor. Accumulating evidence indicates associations between angiogenesis and chronic inflammatory skin diseases. Angiogenesis is deeply involved in the pathogenesis of psoriasis. VEGF, angiopoietins, tumor necrosis factor-a, interleukin-8, and interleukin-17 are unregulated in psoriasis and induce angiogenesis. Angiogenesis may be involved in the pathogenesis of atopic dermatitis, and in particular, mast cells are a major source of VEGF expression. Angiogenesis is an essential process in rosacea, which is induced by LL-37 from a signal cascade by microorganisms, VEGF, and MMP-3 from mast cells. In addition, angiogenesis by increased VEGF has been reported in chronic urticaria and hidradenitis suppurativa. The finding that VEGF is expressed in inflammatory skin lesions indicates that inhibition of angiogenesis is a useful strategy for treatment of chronic, inflammatory skin disorders.
format	article
author	Hyun Ji Lee Yong Jun Hong Miri Kim
author_facet	Hyun Ji Lee Yong Jun Hong Miri Kim
author_sort	Hyun Ji Lee
title	Angiogenesis in Chronic Inflammatory Skin Disorders
title_short	Angiogenesis in Chronic Inflammatory Skin Disorders
title_full	Angiogenesis in Chronic Inflammatory Skin Disorders
title_fullStr	Angiogenesis in Chronic Inflammatory Skin Disorders
title_full_unstemmed	Angiogenesis in Chronic Inflammatory Skin Disorders
title_sort	angiogenesis in chronic inflammatory skin disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a54d6de4fa0f46f786c3b5dedfb49e17
work_keys_str_mv	AT hyunjilee angiogenesisinchronicinflammatoryskindisorders AT yongjunhong angiogenesisinchronicinflammatoryskindisorders AT mirikim angiogenesisinchronicinflammatoryskindisorders
_version_	1718432081964433408

Angiogenesis in Chronic Inflammatory Skin Disorders

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