Identification of inter-organ vascular network: vessels bridging between organs.

Development and homeostasis of organs and whole body is critically dependent on the circulatory system. In particular, the circulatory system, the railways shuttling oxygen and nutrients among various organs, is indispensible for inter-organ humoral communication. Since the modern view of the anatom...

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Autores principales:	Madoka Omae, Norio Takada, Shohei Yamamoto, Hiroyuki Nakajima, Thomas N Sato
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a54f68872b114d848ba6c5d2c926579e
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spelling	oai:doaj.org-article:a54f68872b114d848ba6c5d2c926579e2021-11-18T07:41:42ZIdentification of inter-organ vascular network: vessels bridging between organs.1932-620310.1371/journal.pone.0065720https://doaj.org/article/a54f68872b114d848ba6c5d2c926579e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23799039/?tool=EBIhttps://doaj.org/toc/1932-6203Development and homeostasis of organs and whole body is critically dependent on the circulatory system. In particular, the circulatory system, the railways shuttling oxygen and nutrients among various organs, is indispensible for inter-organ humoral communication. Since the modern view of the anatomy and mechanics of the circulatory system was established in 17(th) century, it has been assumed that humoral factors are carried to and from organs via vascular branches of the central arteries and veins running along the body axis. Over the past few decades, major advances have been made in understanding molecular and cellular mechanisms underlying the vascularization of organs. However, very little is known about how each organ is linked by vasculature (i.e., inter-organ vascular networks). In fact, the exact anatomy of inter-organ vascular networks has remained obscure. Herein, we report the identification of four distinct vessels, V1(LP), V2(LP), V3(LP) and V4(LP), that bridge between two organs, liver and pancreas in developing zebrafish. We found that these inter-organ vessels can be classified into two types: direct and indirect types. The direct type vessels are those that bridge between two organs via single distinct vessel, to which V1(LP) and V2(LP) vessels belong. The indirect type bridges between two organs via separate branches that emanate from a stem vessel, and V3(LP) and V4(LP) vessels belong to this type. Our finding of V1(LP), V2(LP), V3(LP) and V4(LP) vessels provides the proof of the existence of inter-organ vascular networks. These and other yet-to-be-discovered inter-organ vascular networks may facilitate the direct exchange of humoral factors that are necessary for the coordinated growth, differentiation and homeostasis of the connected organs. It is also possible that the inter-organ vessels serve as tracks for their connected organs to follow during their growth to establish their relative positions and size differences.Madoka OmaeNorio TakadaShohei YamamotoHiroyuki NakajimaThomas N SatoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65720 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madoka Omae Norio Takada Shohei Yamamoto Hiroyuki Nakajima Thomas N Sato Identification of inter-organ vascular network: vessels bridging between organs.
description	Development and homeostasis of organs and whole body is critically dependent on the circulatory system. In particular, the circulatory system, the railways shuttling oxygen and nutrients among various organs, is indispensible for inter-organ humoral communication. Since the modern view of the anatomy and mechanics of the circulatory system was established in 17(th) century, it has been assumed that humoral factors are carried to and from organs via vascular branches of the central arteries and veins running along the body axis. Over the past few decades, major advances have been made in understanding molecular and cellular mechanisms underlying the vascularization of organs. However, very little is known about how each organ is linked by vasculature (i.e., inter-organ vascular networks). In fact, the exact anatomy of inter-organ vascular networks has remained obscure. Herein, we report the identification of four distinct vessels, V1(LP), V2(LP), V3(LP) and V4(LP), that bridge between two organs, liver and pancreas in developing zebrafish. We found that these inter-organ vessels can be classified into two types: direct and indirect types. The direct type vessels are those that bridge between two organs via single distinct vessel, to which V1(LP) and V2(LP) vessels belong. The indirect type bridges between two organs via separate branches that emanate from a stem vessel, and V3(LP) and V4(LP) vessels belong to this type. Our finding of V1(LP), V2(LP), V3(LP) and V4(LP) vessels provides the proof of the existence of inter-organ vascular networks. These and other yet-to-be-discovered inter-organ vascular networks may facilitate the direct exchange of humoral factors that are necessary for the coordinated growth, differentiation and homeostasis of the connected organs. It is also possible that the inter-organ vessels serve as tracks for their connected organs to follow during their growth to establish their relative positions and size differences.
format	article
author	Madoka Omae Norio Takada Shohei Yamamoto Hiroyuki Nakajima Thomas N Sato
author_facet	Madoka Omae Norio Takada Shohei Yamamoto Hiroyuki Nakajima Thomas N Sato
author_sort	Madoka Omae
title	Identification of inter-organ vascular network: vessels bridging between organs.
title_short	Identification of inter-organ vascular network: vessels bridging between organs.
title_full	Identification of inter-organ vascular network: vessels bridging between organs.
title_fullStr	Identification of inter-organ vascular network: vessels bridging between organs.
title_full_unstemmed	Identification of inter-organ vascular network: vessels bridging between organs.
title_sort	identification of inter-organ vascular network: vessels bridging between organs.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a54f68872b114d848ba6c5d2c926579e
work_keys_str_mv	AT madokaomae identificationofinterorganvascularnetworkvesselsbridgingbetweenorgans AT noriotakada identificationofinterorganvascularnetworkvesselsbridgingbetweenorgans AT shoheiyamamoto identificationofinterorganvascularnetworkvesselsbridgingbetweenorgans AT hiroyukinakajima identificationofinterorganvascularnetworkvesselsbridgingbetweenorgans AT thomasnsato identificationofinterorganvascularnetworkvesselsbridgingbetweenorgans
_version_	1718423117397753856

Identification of inter-organ vascular network: vessels bridging between organs.

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