Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.

COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases teste...

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Autores principales:	Mariana Perez Duque, Neil J Saad, Héloïse Lucaccioni, Cristina Costa, Geroid McMahon, Firmino Machado, Sooria Balasegaram, Rita Sá Machado
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a54faf3168684983926a17c80504393b
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spelling	oai:doaj.org-article:a54faf3168684983926a17c80504393b2021-12-02T20:12:36ZClinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.1932-620310.1371/journal.pone.0260249https://doaj.org/article/a54faf3168684983926a17c80504393b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260249https://doaj.org/toc/1932-6203COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases tested in mainland Portugal during the first wave of the pandemic, March-April 2020. A multivariable logistic-regression analysis was performed to ascertain the effects of age, sex, prior medical condition and symptoms on the likelihood of testing positive and hospitalisation. Of 25,926 COVID-19 suspected cases included in this study, 5,298 (20%) tested positive. Symptoms were grouped into ten clusters, of which two main ones: one with cough and fever and another with the remainder. There was a higher odds of a positive test with increasing age, myalgia and headache. The odds of being hospitalised increased with age, presence of fever, dyspnoea, or having a prior medical condition although these results varied by region. Presence of cough and other respiratory symptoms did not predict COVID-19 compared to non-COVID respiratory disease patients in any region. Dyspnoea was a strong determinant of hospitalisation, as well as fever and the presence of a prior medical condition, whereas these results varied by region.Mariana Perez DuqueNeil J SaadHéloïse LucaccioniCristina CostaGeroid McMahonFirmino MachadoSooria BalasegaramRita Sá MachadoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260249 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariana Perez Duque Neil J Saad Héloïse Lucaccioni Cristina Costa Geroid McMahon Firmino Machado Sooria Balasegaram Rita Sá Machado Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
description	COVID-19 mainly presents as a respiratory disease with flu-like symptoms, however, recent findings suggest that non-respiratory symptoms can occur early in the infection and cluster together in different groups in different regions. We collected surveillance data among COVID-19 suspected cases tested in mainland Portugal during the first wave of the pandemic, March-April 2020. A multivariable logistic-regression analysis was performed to ascertain the effects of age, sex, prior medical condition and symptoms on the likelihood of testing positive and hospitalisation. Of 25,926 COVID-19 suspected cases included in this study, 5,298 (20%) tested positive. Symptoms were grouped into ten clusters, of which two main ones: one with cough and fever and another with the remainder. There was a higher odds of a positive test with increasing age, myalgia and headache. The odds of being hospitalised increased with age, presence of fever, dyspnoea, or having a prior medical condition although these results varied by region. Presence of cough and other respiratory symptoms did not predict COVID-19 compared to non-COVID respiratory disease patients in any region. Dyspnoea was a strong determinant of hospitalisation, as well as fever and the presence of a prior medical condition, whereas these results varied by region.
format	article
author	Mariana Perez Duque Neil J Saad Héloïse Lucaccioni Cristina Costa Geroid McMahon Firmino Machado Sooria Balasegaram Rita Sá Machado
author_facet	Mariana Perez Duque Neil J Saad Héloïse Lucaccioni Cristina Costa Geroid McMahon Firmino Machado Sooria Balasegaram Rita Sá Machado
author_sort	Mariana Perez Duque
title	Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
title_short	Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
title_full	Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
title_fullStr	Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
title_full_unstemmed	Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.
title_sort	clinical and hospitalisation predictors of covid-19 in the first month of the pandemic, portugal.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a54faf3168684983926a17c80504393b
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Clinical and hospitalisation predictors of COVID-19 in the first month of the pandemic, Portugal.

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