Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas
Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.
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Nature Portfolio
2017
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oai:doaj.org-article:a54fecc0556f4be88b38c63cf07148b52021-12-02T10:47:59ZTherapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas10.1038/s41467-017-00174-72041-1723https://doaj.org/article/a54fecc0556f4be88b38c63cf07148b52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00174-7https://doaj.org/toc/2041-1723Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.Sameer AgnihotriSuganth SuppiahPeter D. TongeShahrzad JalaliArnavaz DaneshJeffery P. BruceYasin MamatjanGeorge KlironomosLior GonenKarolyn AuSheila MansouriSharin KarimiFelix SahmAndreas von DeimlingMichael D. TaylorNormand J. LaperriereTrevor J. PughKenneth D. AldapeGelareh ZadehNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| description |
Radiation-induced meningiomas are often more aggressive than sporadic ones. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors. |
| format |
article |
| author |
Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh |
| author_facet |
Sameer Agnihotri Suganth Suppiah Peter D. Tonge Shahrzad Jalali Arnavaz Danesh Jeffery P. Bruce Yasin Mamatjan George Klironomos Lior Gonen Karolyn Au Sheila Mansouri Sharin Karimi Felix Sahm Andreas von Deimling Michael D. Taylor Normand J. Laperriere Trevor J. Pugh Kenneth D. Aldape Gelareh Zadeh |
| author_sort |
Sameer Agnihotri |
| title |
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| title_short |
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| title_full |
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| title_fullStr |
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| title_full_unstemmed |
Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas |
| title_sort |
therapeutic radiation for childhood cancer drives structural aberrations of nf2 in meningiomas |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a54fecc0556f4be88b38c63cf07148b5 |
| work_keys_str_mv |
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| _version_ |
1718396726170091520 |