ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM

Taking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variantscould determine thrombosis risks both in arterial and venous circulation. The aim of this study wa...

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Autores principales:	A. P. Polyakova, V. M. Shmeleva, M. N. Blinov, V. E. Soldatenkov, V. D. Kargin, L. P. Papayan, S. I. Kapustin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	venous thromboembolism pro-inflammatory cytokines gene polymorphism Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a55034da8bce406eb141fbbe2c6f4874
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spelling	oai:doaj.org-article:a55034da8bce406eb141fbbe2c6f48742021-11-18T08:03:43ZROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM1563-06252313-741X10.15789/1563-0625-2014-2-155-164https://doaj.org/article/a55034da8bce406eb141fbbe2c6f48742014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/681https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTaking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variantscould determine thrombosis risks both in arterial and venous circulation. The aim of this study was to assess possible role of allelic IL-1β, IL-6 and TNFα variants in pathogenesis of venous thromboembolism (VTE)in young patients. A retrospective analysis was performed for a group of 180 patients with early-onset VTE, and 150 healthy. In a sub-group with deep-vein thrombosis of lower extremities (DWTLE) complicated bypulmonary artery thromboembolia (PAT), we have revealed increased frequencies of IL-6 –174C homozygotes (30.8% vs 13.0%, p = 0.02) and IL-1β –31Т (61.5% vs 40.9%, p = 0.03), when compared with a subgroup of DWTLE. Among patients with “isolated” PAT a tendency for increased IL-1β –31ТТ ratio was found, as compared with DWTLE (53.8% vs 40.9%, р = 0,3), like as with control group (53.8% vs 40.7%, р = 0,3), These differences, however, were statistically insignificant. These data may suggest certain effects of IL-1β and IL-6 gene polymorphisms upon clinical characteristics of venous thromboembolism, rather than upon general VTE risk among young persons.A. P. PolyakovaV. M. ShmelevaM. N. BlinovV. E. SoldatenkovV. D. KarginL. P. PapayanS. I. KapustinSPb RAACIarticlevenous thromboembolismpro-inflammatory cytokinesgenepolymorphismImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 155-164 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	venous thromboembolism pro-inflammatory cytokines gene polymorphism Immunologic diseases. Allergy RC581-607
spellingShingle	venous thromboembolism pro-inflammatory cytokines gene polymorphism Immunologic diseases. Allergy RC581-607 A. P. Polyakova V. M. Shmeleva M. N. Blinov V. E. Soldatenkov V. D. Kargin L. P. Papayan S. I. Kapustin ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
description	Taking into account interrelations between inflammation and hemostasis, as well as immediate effects of IL-1β, IL-6 and TNFα upon blood coagulation system, one may suggest that their functional variantscould determine thrombosis risks both in arterial and venous circulation. The aim of this study was to assess possible role of allelic IL-1β, IL-6 and TNFα variants in pathogenesis of venous thromboembolism (VTE)in young patients. A retrospective analysis was performed for a group of 180 patients with early-onset VTE, and 150 healthy. In a sub-group with deep-vein thrombosis of lower extremities (DWTLE) complicated bypulmonary artery thromboembolia (PAT), we have revealed increased frequencies of IL-6 –174C homozygotes (30.8% vs 13.0%, p = 0.02) and IL-1β –31Т (61.5% vs 40.9%, p = 0.03), when compared with a subgroup of DWTLE. Among patients with “isolated” PAT a tendency for increased IL-1β –31ТТ ratio was found, as compared with DWTLE (53.8% vs 40.9%, р = 0,3), like as with control group (53.8% vs 40.7%, р = 0,3), These differences, however, were statistically insignificant. These data may suggest certain effects of IL-1β and IL-6 gene polymorphisms upon clinical characteristics of venous thromboembolism, rather than upon general VTE risk among young persons.
format	article
author	A. P. Polyakova V. M. Shmeleva M. N. Blinov V. E. Soldatenkov V. D. Kargin L. P. Papayan S. I. Kapustin
author_facet	A. P. Polyakova V. M. Shmeleva M. N. Blinov V. E. Soldatenkov V. D. Kargin L. P. Papayan S. I. Kapustin
author_sort	A. P. Polyakova
title	ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
title_short	ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
title_full	ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
title_fullStr	ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
title_full_unstemmed	ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM
title_sort	role of pro-inflammatory cytokine gene polymorphisms in patients with early-onset venous thromboembolism
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a55034da8bce406eb141fbbe2c6f4874
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ROLE OF PRO-INFLAMMATORY CYTOKINE GENE POLYMORPHISMS IN PATIENTS WITH EARLY-ONSET VENOUS THROMBOEMBOLISM

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