Helminth colonization is associated with increased diversity of the gut microbiota.
Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presen...
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2014
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oai:doaj.org-article:a5505b5b0aa240f894d65ab86d6a07ac2021-11-18T09:16:03ZHelminth colonization is associated with increased diversity of the gut microbiota.1935-27271935-273510.1371/journal.pntd.0002880https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac2014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24851867/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presence of helminths, since they predominantly infect individuals from developing countries, such as the indigenous communities in Malaysia we examine in this work. We compared the composition and diversity of bacterial communities from the fecal microbiota of 51 people from two villages in Malaysia, of which 36 (70.6%) were infected by helminths. The 16S rRNA V4 region was sequenced at an average of nineteen thousand sequences per samples. Helminth-colonized individuals had greater species richness and number of observed OTUs with enrichment of Paraprevotellaceae, especially with Trichuris infection. We developed a new approach of combining centered log-ratio (clr) transformation for OTU relative abundances with sparse Partial Least Squares Discriminant Analysis (sPLS-DA) to enable more robust predictions of OTU interrelationships. These results suggest that helminths may have an impact on the diversity, bacterial community structure and function of the gut microbiota.Soo Ching LeeMei San TangYvonne A L LimSeow Huey ChoyZachary D KurtzLaura M CoxUma Mahesh GundraIlseung ChoRichard BonneauMartin J BlaserKek Heng ChuaP'ng LokePublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2880 (2014) |
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| topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
| spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke Helminth colonization is associated with increased diversity of the gut microbiota. |
| description |
Soil-transmitted helminths colonize more than 1.5 billion people worldwide, yet little is known about how they interact with bacterial communities in the gut microbiota. Differences in the gut microbiota between individuals living in developed and developing countries may be partly due to the presence of helminths, since they predominantly infect individuals from developing countries, such as the indigenous communities in Malaysia we examine in this work. We compared the composition and diversity of bacterial communities from the fecal microbiota of 51 people from two villages in Malaysia, of which 36 (70.6%) were infected by helminths. The 16S rRNA V4 region was sequenced at an average of nineteen thousand sequences per samples. Helminth-colonized individuals had greater species richness and number of observed OTUs with enrichment of Paraprevotellaceae, especially with Trichuris infection. We developed a new approach of combining centered log-ratio (clr) transformation for OTU relative abundances with sparse Partial Least Squares Discriminant Analysis (sPLS-DA) to enable more robust predictions of OTU interrelationships. These results suggest that helminths may have an impact on the diversity, bacterial community structure and function of the gut microbiota. |
| format |
article |
| author |
Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke |
| author_facet |
Soo Ching Lee Mei San Tang Yvonne A L Lim Seow Huey Choy Zachary D Kurtz Laura M Cox Uma Mahesh Gundra Ilseung Cho Richard Bonneau Martin J Blaser Kek Heng Chua P'ng Loke |
| author_sort |
Soo Ching Lee |
| title |
Helminth colonization is associated with increased diversity of the gut microbiota. |
| title_short |
Helminth colonization is associated with increased diversity of the gut microbiota. |
| title_full |
Helminth colonization is associated with increased diversity of the gut microbiota. |
| title_fullStr |
Helminth colonization is associated with increased diversity of the gut microbiota. |
| title_full_unstemmed |
Helminth colonization is associated with increased diversity of the gut microbiota. |
| title_sort |
helminth colonization is associated with increased diversity of the gut microbiota. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/a5505b5b0aa240f894d65ab86d6a07ac |
| work_keys_str_mv |
AT soochinglee helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT meisantang helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT yvonneallim helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT seowhueychoy helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT zacharydkurtz helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT lauramcox helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT umamaheshgundra helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT ilseungcho helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT richardbonneau helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT martinjblaser helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT kekhengchua helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota AT pngloke helminthcolonizationisassociatedwithincreaseddiversityofthegutmicrobiota |
| _version_ |
1718420919154638848 |