Exploring the Hereditary Nature of Migraine

Charlene Bron, Heidi G Sutherland, Lyn R Griffiths Queensland University of Technology (QUT), Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland, 4059, AustraliaCorrespondence: Lyn R Griffith...

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Autores principales:	Bron C, Sutherland HG, Griffiths LR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	migraine migraine without aura migraine with aura familial hemiplegic migraine x-linked mitochondrial variants epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a5539f4f574541b9b81b48858753ed3f
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spelling	oai:doaj.org-article:a5539f4f574541b9b81b48858753ed3f2021-12-02T18:31:08ZExploring the Hereditary Nature of Migraine1178-2021https://doaj.org/article/a5539f4f574541b9b81b48858753ed3f2021-04-01T00:00:00Zhttps://www.dovepress.com/exploring-the-hereditary-nature-of-migraine-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Charlene Bron, Heidi G Sutherland, Lyn R Griffiths Queensland University of Technology (QUT), Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland, 4059, AustraliaCorrespondence: Lyn R Griffiths Tel +617 3138 6102Fax +617 3138 6039Email lyn.griffiths@qut.edu.auAbstract: Migraine is a common neurological disorder which affects 15– 20% of the population; it has a high socioeconomic impact through treatment and loss of productivity. Current forms of diagnosis are primarily clinical and can be difficult owing to comorbidity and symptom overlap with other neurological disorders. As such, there is a need for better diagnostic tools in the form of genetic testing. Migraine is a complex disorder, encompassing various subtypes, and has a large genetic component. Genetic studies conducted on rare monogenic subtypes, including familial hemiplegic migraine, have led to insights into its pathogenesis via identification of causal mutations in three genes (CACNA1A, ATP1A2 and SCN1A) that are involved in transport of ions at synapses and glutamatergic transmission. Study of familial migraine with aura pedigrees has also revealed other causal genes for monogenic forms of migraine. With respect to the more common polygenic form of migraine, large genome-wide association studies have increased our understanding of the genes, pathways and mechanisms involved in susceptibility, which are largely involved in neuronal and vascular functions. Given the preponderance of female migraineurs (3:1), there is evidence to suggest that hormonal or X-linked components can also contribute to migraine, and the role of genetic variants in mitochondrial DNA in migraine has been another avenue of exploration. Epigenetic studies of migraine have shown links between hormonal variation and alterations in DNA methylation and gene expression. While there is an abundance of preliminary studies identifying many potentially causative migraine genes and pathways, more comprehensive genomic and functional analysis to better understand mechanisms may aid in better diagnostic and treatment outcomes.Keywords: migraine, migraine without aura, migraine with aura, familial hemiplegic migraine, X-linked, mitochondrial variants, epigeneticsBron CSutherland HGGriffiths LRDove Medical Pressarticlemigrainemigraine without auramigraine with aurafamilial hemiplegic migrainex-linkedmitochondrial variantsepigeneticsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1183-1194 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	migraine migraine without aura migraine with aura familial hemiplegic migraine x-linked mitochondrial variants epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	migraine migraine without aura migraine with aura familial hemiplegic migraine x-linked mitochondrial variants epigenetics Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bron C Sutherland HG Griffiths LR Exploring the Hereditary Nature of Migraine
description	Charlene Bron, Heidi G Sutherland, Lyn R Griffiths Queensland University of Technology (QUT), Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland, 4059, AustraliaCorrespondence: Lyn R Griffiths Tel +617 3138 6102Fax +617 3138 6039Email lyn.griffiths@qut.edu.auAbstract: Migraine is a common neurological disorder which affects 15– 20% of the population; it has a high socioeconomic impact through treatment and loss of productivity. Current forms of diagnosis are primarily clinical and can be difficult owing to comorbidity and symptom overlap with other neurological disorders. As such, there is a need for better diagnostic tools in the form of genetic testing. Migraine is a complex disorder, encompassing various subtypes, and has a large genetic component. Genetic studies conducted on rare monogenic subtypes, including familial hemiplegic migraine, have led to insights into its pathogenesis via identification of causal mutations in three genes (CACNA1A, ATP1A2 and SCN1A) that are involved in transport of ions at synapses and glutamatergic transmission. Study of familial migraine with aura pedigrees has also revealed other causal genes for monogenic forms of migraine. With respect to the more common polygenic form of migraine, large genome-wide association studies have increased our understanding of the genes, pathways and mechanisms involved in susceptibility, which are largely involved in neuronal and vascular functions. Given the preponderance of female migraineurs (3:1), there is evidence to suggest that hormonal or X-linked components can also contribute to migraine, and the role of genetic variants in mitochondrial DNA in migraine has been another avenue of exploration. Epigenetic studies of migraine have shown links between hormonal variation and alterations in DNA methylation and gene expression. While there is an abundance of preliminary studies identifying many potentially causative migraine genes and pathways, more comprehensive genomic and functional analysis to better understand mechanisms may aid in better diagnostic and treatment outcomes.Keywords: migraine, migraine without aura, migraine with aura, familial hemiplegic migraine, X-linked, mitochondrial variants, epigenetics
format	article
author	Bron C Sutherland HG Griffiths LR
author_facet	Bron C Sutherland HG Griffiths LR
author_sort	Bron C
title	Exploring the Hereditary Nature of Migraine
title_short	Exploring the Hereditary Nature of Migraine
title_full	Exploring the Hereditary Nature of Migraine
title_fullStr	Exploring the Hereditary Nature of Migraine
title_full_unstemmed	Exploring the Hereditary Nature of Migraine
title_sort	exploring the hereditary nature of migraine
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a5539f4f574541b9b81b48858753ed3f
work_keys_str_mv	AT bronc exploringthehereditarynatureofmigraine AT sutherlandhg exploringthehereditarynatureofmigraine AT griffithslr exploringthehereditarynatureofmigraine
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Exploring the Hereditary Nature of Migraine

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