Blood Eosinophils and Pulmonary Rehabilitation in COPD

Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml)...

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Autores principales: Jafar Aljazeeri, Abdullah Sakkat, Nima Makhdami, Rayyan Almusally, Frederick Morfaw, Andrew McIvor
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Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/a555f81e4786475287dfb605f3dd82b9
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spelling oai:doaj.org-article:a555f81e4786475287dfb605f3dd82b92021-11-15T01:19:35ZBlood Eosinophils and Pulmonary Rehabilitation in COPD1916-724510.1155/2021/7449527https://doaj.org/article/a555f81e4786475287dfb605f3dd82b92021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7449527https://doaj.org/toc/1916-7245Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml) or noneosinophilic (<300 cells/ml). In a retrospective design, we compared changes within and between the two groups on BODE index, 6-minute walk test (6MWT), FEV1, and mMRC dyspnea scale. Results. Of 206 patients enrolled, 176 were included for analysis; 90 were eosinophilic. BODE index improved in both groups: (MD −1.25; 95% CI (−0.45, −4.25), P≤0.001) in the eosinophilic and (MD −1.33; 95% CI (−1.72, −0.94), P≤0.001) in the noneosinophilic, but a higher BODE index remained in the eosinophilic (4.98); adjusted mean change (β): 0.7 (95% CI (0.15, 1.26), P=0.01). 6MWT improved by 29.3 m in the eosinophilic (95% CI (14.2, 44.4), P≤0.001) vs. 115.1 m in the noneosinophilic (95% CI (−30.4, 260.6), P=0.12). FEV1 did not change in the eosinophilic (MD −0.6; 95% CI (−2.64, 1.48), P=0.58), but improved by 2.5% in the noneosinophilic (MD 2.5; 95% CI (0.77, 4.17), P=0.005). There were no significant between-group differences in 6MWT and FEV1; adjusted mean changes (β) were −9.69 m (95% CI (−39.51, 20.14), P=0.52) and −2.31% (95% CI (−5.69, 1.08), P=0.18), respectively. There were no significant within- or between-group changes in the mMRC scale. Conclusion. Although PR improves the BODE index in both eosinophilic and noneosinophilic COPD, a higher eosinophil count (≥300 cells/ml) is associated with a higher (worse) BODE index. Blood eosinophils may predict PR outcomes.Jafar AljazeeriAbdullah SakkatNima MakhdamiRayyan AlmusallyFrederick MorfawAndrew McIvorHindawi LimitedarticleDiseases of the respiratory systemRC705-779ENCanadian Respiratory Journal, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Diseases of the respiratory system
RC705-779
spellingShingle Diseases of the respiratory system
RC705-779
Jafar Aljazeeri
Abdullah Sakkat
Nima Makhdami
Rayyan Almusally
Frederick Morfaw
Andrew McIvor
Blood Eosinophils and Pulmonary Rehabilitation in COPD
description Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml) or noneosinophilic (<300 cells/ml). In a retrospective design, we compared changes within and between the two groups on BODE index, 6-minute walk test (6MWT), FEV1, and mMRC dyspnea scale. Results. Of 206 patients enrolled, 176 were included for analysis; 90 were eosinophilic. BODE index improved in both groups: (MD −1.25; 95% CI (−0.45, −4.25), P≤0.001) in the eosinophilic and (MD −1.33; 95% CI (−1.72, −0.94), P≤0.001) in the noneosinophilic, but a higher BODE index remained in the eosinophilic (4.98); adjusted mean change (β): 0.7 (95% CI (0.15, 1.26), P=0.01). 6MWT improved by 29.3 m in the eosinophilic (95% CI (14.2, 44.4), P≤0.001) vs. 115.1 m in the noneosinophilic (95% CI (−30.4, 260.6), P=0.12). FEV1 did not change in the eosinophilic (MD −0.6; 95% CI (−2.64, 1.48), P=0.58), but improved by 2.5% in the noneosinophilic (MD 2.5; 95% CI (0.77, 4.17), P=0.005). There were no significant between-group differences in 6MWT and FEV1; adjusted mean changes (β) were −9.69 m (95% CI (−39.51, 20.14), P=0.52) and −2.31% (95% CI (−5.69, 1.08), P=0.18), respectively. There were no significant within- or between-group changes in the mMRC scale. Conclusion. Although PR improves the BODE index in both eosinophilic and noneosinophilic COPD, a higher eosinophil count (≥300 cells/ml) is associated with a higher (worse) BODE index. Blood eosinophils may predict PR outcomes.
format article
author Jafar Aljazeeri
Abdullah Sakkat
Nima Makhdami
Rayyan Almusally
Frederick Morfaw
Andrew McIvor
author_facet Jafar Aljazeeri
Abdullah Sakkat
Nima Makhdami
Rayyan Almusally
Frederick Morfaw
Andrew McIvor
author_sort Jafar Aljazeeri
title Blood Eosinophils and Pulmonary Rehabilitation in COPD
title_short Blood Eosinophils and Pulmonary Rehabilitation in COPD
title_full Blood Eosinophils and Pulmonary Rehabilitation in COPD
title_fullStr Blood Eosinophils and Pulmonary Rehabilitation in COPD
title_full_unstemmed Blood Eosinophils and Pulmonary Rehabilitation in COPD
title_sort blood eosinophils and pulmonary rehabilitation in copd
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/a555f81e4786475287dfb605f3dd82b9
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AT abdullahsakkat bloodeosinophilsandpulmonaryrehabilitationincopd
AT nimamakhdami bloodeosinophilsandpulmonaryrehabilitationincopd
AT rayyanalmusally bloodeosinophilsandpulmonaryrehabilitationincopd
AT frederickmorfaw bloodeosinophilsandpulmonaryrehabilitationincopd
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