Blood Eosinophils and Pulmonary Rehabilitation in COPD
Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml)...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Hindawi Limited
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a555f81e4786475287dfb605f3dd82b9 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:a555f81e4786475287dfb605f3dd82b9 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:a555f81e4786475287dfb605f3dd82b92021-11-15T01:19:35ZBlood Eosinophils and Pulmonary Rehabilitation in COPD1916-724510.1155/2021/7449527https://doaj.org/article/a555f81e4786475287dfb605f3dd82b92021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7449527https://doaj.org/toc/1916-7245Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml) or noneosinophilic (<300 cells/ml). In a retrospective design, we compared changes within and between the two groups on BODE index, 6-minute walk test (6MWT), FEV1, and mMRC dyspnea scale. Results. Of 206 patients enrolled, 176 were included for analysis; 90 were eosinophilic. BODE index improved in both groups: (MD −1.25; 95% CI (−0.45, −4.25), P≤0.001) in the eosinophilic and (MD −1.33; 95% CI (−1.72, −0.94), P≤0.001) in the noneosinophilic, but a higher BODE index remained in the eosinophilic (4.98); adjusted mean change (β): 0.7 (95% CI (0.15, 1.26), P=0.01). 6MWT improved by 29.3 m in the eosinophilic (95% CI (14.2, 44.4), P≤0.001) vs. 115.1 m in the noneosinophilic (95% CI (−30.4, 260.6), P=0.12). FEV1 did not change in the eosinophilic (MD −0.6; 95% CI (−2.64, 1.48), P=0.58), but improved by 2.5% in the noneosinophilic (MD 2.5; 95% CI (0.77, 4.17), P=0.005). There were no significant between-group differences in 6MWT and FEV1; adjusted mean changes (β) were −9.69 m (95% CI (−39.51, 20.14), P=0.52) and −2.31% (95% CI (−5.69, 1.08), P=0.18), respectively. There were no significant within- or between-group changes in the mMRC scale. Conclusion. Although PR improves the BODE index in both eosinophilic and noneosinophilic COPD, a higher eosinophil count (≥300 cells/ml) is associated with a higher (worse) BODE index. Blood eosinophils may predict PR outcomes.Jafar AljazeeriAbdullah SakkatNima MakhdamiRayyan AlmusallyFrederick MorfawAndrew McIvorHindawi LimitedarticleDiseases of the respiratory systemRC705-779ENCanadian Respiratory Journal, Vol 2021 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Diseases of the respiratory system RC705-779 |
spellingShingle |
Diseases of the respiratory system RC705-779 Jafar Aljazeeri Abdullah Sakkat Nima Makhdami Rayyan Almusally Frederick Morfaw Andrew McIvor Blood Eosinophils and Pulmonary Rehabilitation in COPD |
description |
Background. Blood eosinophils predict the response to therapy, risk of exacerbation, and readmission in COPD. This study investigates whether blood eosinophils predict pulmonary rehabilitation (PR) outcomes in COPD. Methods. We categorized patients into eosinophilic (blood eosinophils ≥300 cells/ml) or noneosinophilic (<300 cells/ml). In a retrospective design, we compared changes within and between the two groups on BODE index, 6-minute walk test (6MWT), FEV1, and mMRC dyspnea scale. Results. Of 206 patients enrolled, 176 were included for analysis; 90 were eosinophilic. BODE index improved in both groups: (MD −1.25; 95% CI (−0.45, −4.25), P≤0.001) in the eosinophilic and (MD −1.33; 95% CI (−1.72, −0.94), P≤0.001) in the noneosinophilic, but a higher BODE index remained in the eosinophilic (4.98); adjusted mean change (β): 0.7 (95% CI (0.15, 1.26), P=0.01). 6MWT improved by 29.3 m in the eosinophilic (95% CI (14.2, 44.4), P≤0.001) vs. 115.1 m in the noneosinophilic (95% CI (−30.4, 260.6), P=0.12). FEV1 did not change in the eosinophilic (MD −0.6; 95% CI (−2.64, 1.48), P=0.58), but improved by 2.5% in the noneosinophilic (MD 2.5; 95% CI (0.77, 4.17), P=0.005). There were no significant between-group differences in 6MWT and FEV1; adjusted mean changes (β) were −9.69 m (95% CI (−39.51, 20.14), P=0.52) and −2.31% (95% CI (−5.69, 1.08), P=0.18), respectively. There were no significant within- or between-group changes in the mMRC scale. Conclusion. Although PR improves the BODE index in both eosinophilic and noneosinophilic COPD, a higher eosinophil count (≥300 cells/ml) is associated with a higher (worse) BODE index. Blood eosinophils may predict PR outcomes. |
format |
article |
author |
Jafar Aljazeeri Abdullah Sakkat Nima Makhdami Rayyan Almusally Frederick Morfaw Andrew McIvor |
author_facet |
Jafar Aljazeeri Abdullah Sakkat Nima Makhdami Rayyan Almusally Frederick Morfaw Andrew McIvor |
author_sort |
Jafar Aljazeeri |
title |
Blood Eosinophils and Pulmonary Rehabilitation in COPD |
title_short |
Blood Eosinophils and Pulmonary Rehabilitation in COPD |
title_full |
Blood Eosinophils and Pulmonary Rehabilitation in COPD |
title_fullStr |
Blood Eosinophils and Pulmonary Rehabilitation in COPD |
title_full_unstemmed |
Blood Eosinophils and Pulmonary Rehabilitation in COPD |
title_sort |
blood eosinophils and pulmonary rehabilitation in copd |
publisher |
Hindawi Limited |
publishDate |
2021 |
url |
https://doaj.org/article/a555f81e4786475287dfb605f3dd82b9 |
work_keys_str_mv |
AT jafaraljazeeri bloodeosinophilsandpulmonaryrehabilitationincopd AT abdullahsakkat bloodeosinophilsandpulmonaryrehabilitationincopd AT nimamakhdami bloodeosinophilsandpulmonaryrehabilitationincopd AT rayyanalmusally bloodeosinophilsandpulmonaryrehabilitationincopd AT frederickmorfaw bloodeosinophilsandpulmonaryrehabilitationincopd AT andrewmcivor bloodeosinophilsandpulmonaryrehabilitationincopd |
_version_ |
1718428940972851200 |