Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts

Quantitative PCR-based strategies are typically effective for monitoring BCR-ABL1 transcript levels in chronic myeloid leukemia (CML). Additionally, some patients treated with tyrosine kinase inhibitors can experience long-term treatment-free remission after discontinuation of the inhibitor. However...

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Autores principales:	Brittany M. Smith, Diana Brewer, Brian J. Druker, Theodore P. Braun
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	bcr-abl transcript minimal residual disease chronic myeloid leukemia tyrosine kinase inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a5563c1352414c0a91e3f2aa95e42492
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spelling	oai:doaj.org-article:a5563c1352414c0a91e3f2aa95e424922021-12-02T12:40:23ZNavigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts1662-657510.1159/000520400https://doaj.org/article/a5563c1352414c0a91e3f2aa95e424922021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520400https://doaj.org/toc/1662-6575Quantitative PCR-based strategies are typically effective for monitoring BCR-ABL1 transcript levels in chronic myeloid leukemia (CML). Additionally, some patients treated with tyrosine kinase inhibitors can experience long-term treatment-free remission after discontinuation of the inhibitor. However, this outcome hinges on effectively monitoring the patient’s response to therapy. We present a patient with CML and multiple BCR-ABL1 transcripts, including a rare isoform that lacks qPCR standardization. We describe unexpected discrepancies in transcript quantification, further having an impact on clinical decision-making regarding duration of treatment. To better inform clinical practice, we suggest monitoring patients at the same testing facility to better track transcript trend.Brittany M. SmithDiana BrewerBrian J. DrukerTheodore P. BraunKarger Publishersarticlebcr-abl transcriptminimal residual diseasechronic myeloid leukemiatyrosine kinase inhibitorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1707-1711 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bcr-abl transcript minimal residual disease chronic myeloid leukemia tyrosine kinase inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	bcr-abl transcript minimal residual disease chronic myeloid leukemia tyrosine kinase inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Brittany M. Smith Diana Brewer Brian J. Druker Theodore P. Braun Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
description	Quantitative PCR-based strategies are typically effective for monitoring BCR-ABL1 transcript levels in chronic myeloid leukemia (CML). Additionally, some patients treated with tyrosine kinase inhibitors can experience long-term treatment-free remission after discontinuation of the inhibitor. However, this outcome hinges on effectively monitoring the patient’s response to therapy. We present a patient with CML and multiple BCR-ABL1 transcripts, including a rare isoform that lacks qPCR standardization. We describe unexpected discrepancies in transcript quantification, further having an impact on clinical decision-making regarding duration of treatment. To better inform clinical practice, we suggest monitoring patients at the same testing facility to better track transcript trend.
format	article
author	Brittany M. Smith Diana Brewer Brian J. Druker Theodore P. Braun
author_facet	Brittany M. Smith Diana Brewer Brian J. Druker Theodore P. Braun
author_sort	Brittany M. Smith
title	Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
title_short	Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
title_full	Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
title_fullStr	Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
title_full_unstemmed	Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts
title_sort	navigating challenges in monitoring chronic myeloid leukemia with multiple bcr-abl1 transcripts
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/a5563c1352414c0a91e3f2aa95e42492
work_keys_str_mv	AT brittanymsmith navigatingchallengesinmonitoringchronicmyeloidleukemiawithmultiplebcrabl1transcripts AT dianabrewer navigatingchallengesinmonitoringchronicmyeloidleukemiawithmultiplebcrabl1transcripts AT brianjdruker navigatingchallengesinmonitoringchronicmyeloidleukemiawithmultiplebcrabl1transcripts AT theodorepbraun navigatingchallengesinmonitoringchronicmyeloidleukemiawithmultiplebcrabl1transcripts
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Navigating Challenges in Monitoring Chronic Myeloid Leukemia with Multiple BCR-ABL1 Transcripts

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