ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM
Chang Guo, Li Zhao, Yi Ding, Zhicong Zhao, Chenxi Wang, Lian Li, Zhensheng Cai, Yanyan Li, Hong Xia, ZhuanZhuan Zhu, Fan Yu, Meiqing Dai, Xia Deng, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of ChinaCorr...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a55713452fe94295894d4ddd3cdee6cd |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a55713452fe94295894d4ddd3cdee6cd |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a55713452fe94295894d4ddd3cdee6cd2021-12-02T12:58:52ZANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM1178-7007https://doaj.org/article/a55713452fe94295894d4ddd3cdee6cd2020-11-01T00:00:00Zhttps://www.dovepress.com/angptl8-gene-polymorphism-rs2278426-is-related-to-carotid-intimandashm-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chang Guo, Li Zhao, Yi Ding, Zhicong Zhao, Chenxi Wang, Lian Li, Zhensheng Cai, Yanyan Li, Hong Xia, ZhuanZhuan Zhu, Fan Yu, Meiqing Dai, Xia Deng, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of ChinaCorrespondence: Guoyue YuanDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-135-0528-9352Email yuanguoyue@ujs.edu.cnXia DengDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of ChinaEmail dengxia11@outlook.comAim: ANGPTL8 is a cytokine expressed and secreted by liver and adipose tissue, and is involved in glucose, lipid, and energy metabolism. Although studies have shown that ANGPTL8 is elevated in type 2 diabetes mellitus (T2DM) and cardiovascular disease, few have examined the association between ANGPTL8 single-nucleotide polymorphisms and the risk of macrovascular complications in T2DM patients. This study aimed to explore the relationship between rs2278426 and carotid intima–media thickening (cIMT) in T2DM.Methods: A total of 217 T2DM patients and 201 healthy control subjects with normal glucose tolerance were recruited in the study. T2DM patients were divided into two groups: T2DM patients without cIM thickening (cIMT < 1 mm, 109 cases) and T2DM patients with cIM thickening (cIMT ≥ 1 mm, 108 cases). rs2278426 genotypes in all 418 subjects were determined and the risk of T2DM and T2DM with cIM thickening analyzed.Results: CT+TT-genotype frequency in T2DM was higher than in controls with normal glucose tolerance, and the proportion of the CT+TT genotype in the group with cIMT was higher than in the group (P< 0.05). In addition, T alleles were associated with waist:hip ratio, triglycerides, high density–lipoprotein cholesterol, plasma glucose at 2 hours’ oral glucose tolerance, and homeostatic model assessment of insulin resistance (P< 0.05).Conclusion: Generally, carriers of the T allele at rs2278426 are more likely to develop T2DM, and the risk of cIM thickening is significantly increased for T-allele carriers with T2DM, which indicates an increased risk of macroangiopathy.Keywords: type 2 diabetes mellitus, angiopoietin‑like protein 8, carotid intima–media thickness, polymorphism, rs2278426Guo CZhao LDing YZhao ZWang CLi LCai ZLi YXia HZhu ZZYu FDai MDeng XYuan GDove Medical Pressarticletype 2 diabetes mellitusangiopoietin‑like protein 8carotid intima-media thicknesspolymorphismrs2278426Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4519-4528 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
type 2 diabetes mellitus angiopoietin‑like protein 8 carotid intima-media thickness polymorphism rs2278426 Specialties of internal medicine RC581-951 |
| spellingShingle |
type 2 diabetes mellitus angiopoietin‑like protein 8 carotid intima-media thickness polymorphism rs2278426 Specialties of internal medicine RC581-951 Guo C Zhao L Ding Y Zhao Z Wang C Li L Cai Z Li Y Xia H Zhu ZZ Yu F Dai M Deng X Yuan G ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| description |
Chang Guo, Li Zhao, Yi Ding, Zhicong Zhao, Chenxi Wang, Lian Li, Zhensheng Cai, Yanyan Li, Hong Xia, ZhuanZhuan Zhu, Fan Yu, Meiqing Dai, Xia Deng, Guoyue Yuan Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of ChinaCorrespondence: Guoyue YuanDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaTel +86-135-0528-9352Email yuanguoyue@ujs.edu.cnXia DengDepartment of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People’s Republic of ChinaEmail dengxia11@outlook.comAim: ANGPTL8 is a cytokine expressed and secreted by liver and adipose tissue, and is involved in glucose, lipid, and energy metabolism. Although studies have shown that ANGPTL8 is elevated in type 2 diabetes mellitus (T2DM) and cardiovascular disease, few have examined the association between ANGPTL8 single-nucleotide polymorphisms and the risk of macrovascular complications in T2DM patients. This study aimed to explore the relationship between rs2278426 and carotid intima–media thickening (cIMT) in T2DM.Methods: A total of 217 T2DM patients and 201 healthy control subjects with normal glucose tolerance were recruited in the study. T2DM patients were divided into two groups: T2DM patients without cIM thickening (cIMT < 1 mm, 109 cases) and T2DM patients with cIM thickening (cIMT ≥ 1 mm, 108 cases). rs2278426 genotypes in all 418 subjects were determined and the risk of T2DM and T2DM with cIM thickening analyzed.Results: CT+TT-genotype frequency in T2DM was higher than in controls with normal glucose tolerance, and the proportion of the CT+TT genotype in the group with cIMT was higher than in the group (P< 0.05). In addition, T alleles were associated with waist:hip ratio, triglycerides, high density–lipoprotein cholesterol, plasma glucose at 2 hours’ oral glucose tolerance, and homeostatic model assessment of insulin resistance (P< 0.05).Conclusion: Generally, carriers of the T allele at rs2278426 are more likely to develop T2DM, and the risk of cIM thickening is significantly increased for T-allele carriers with T2DM, which indicates an increased risk of macroangiopathy.Keywords: type 2 diabetes mellitus, angiopoietin‑like protein 8, carotid intima–media thickness, polymorphism, rs2278426 |
| format |
article |
| author |
Guo C Zhao L Ding Y Zhao Z Wang C Li L Cai Z Li Y Xia H Zhu ZZ Yu F Dai M Deng X Yuan G |
| author_facet |
Guo C Zhao L Ding Y Zhao Z Wang C Li L Cai Z Li Y Xia H Zhu ZZ Yu F Dai M Deng X Yuan G |
| author_sort |
Guo C |
| title |
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| title_short |
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| title_full |
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| title_fullStr |
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| title_full_unstemmed |
ANGPTL8 Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM |
| title_sort |
angptl8 gene polymorphism rs2278426 is related to carotid intima–media thickness in t2dm |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/a55713452fe94295894d4ddd3cdee6cd |
| work_keys_str_mv |
AT guoc angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT zhaol angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT dingy angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT zhaoz angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT wangc angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT lil angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT caiz angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT liy angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT xiah angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT zhuzz angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT yuf angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT daim angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT dengx angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm AT yuang angptl8genepolymorphismrs2278426isrelatedtocarotidintimandashmediathicknessint2dm |
| _version_ |
1718393584777953280 |