Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus

Preethi Rajan, Harly Greenberg Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Hofstra-North Shore LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Obstructive sleep apnea (OSA) is independently associated with cardiovascular and cardiometabolic risk in sever...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rajan P, Greenberg H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/a55750ab71bc4518922579836c847852
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a55750ab71bc4518922579836c847852
record_format	dspace
spelling	oai:doaj.org-article:a55750ab71bc4518922579836c8478522021-12-02T02:42:44ZObstructive sleep apnea as a risk factor for type 2 diabetes mellitus1179-1608https://doaj.org/article/a55750ab71bc4518922579836c8478522015-10-01T00:00:00Zhttps://www.dovepress.com/obstructive-sleep-apnea-as-a-risk-factor-for-type-2-diabetes-mellitus-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Preethi Rajan, Harly Greenberg Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Hofstra-North Shore LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Obstructive sleep apnea (OSA) is independently associated with cardiovascular and cardiometabolic risk in several large epidemiologic studies. OSA leads to several physiologic disturbances such as intermittent hypoxia, sleep fragmentation, and increase in autonomic tone. These disturbances have been associated with insulin resistance and type 2 diabetes mellitus (T2DM) in animal and human studies. Studies also suggest a bidirectional relationship between OSA and T2DM whereby T2DM itself might contribute to the features of OSA. Moreover, successful treatment of OSA may reduce these risks, although this is controversial. The purpose of this article is to review 1) the links and bidirectional associations between OSA and T2DM; 2) the pathogenic mechanisms that might link these two disease states; 3) the role of continuous positive airway pressure therapy in improving glucose tolerance, sensitivity, and resistance; and 4) the implications for clinical practice. Keywords: Insulin resistance, metabolic syndrome, sleep disordered breathing, intermittent hypoxiaRajan PGreenberg HDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2015, Iss default, Pp 113-125 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Rajan P Greenberg H Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
description	Preethi Rajan, Harly Greenberg Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Hofstra-North Shore LIJ School of Medicine, New Hyde Park, NY, USA Abstract: Obstructive sleep apnea (OSA) is independently associated with cardiovascular and cardiometabolic risk in several large epidemiologic studies. OSA leads to several physiologic disturbances such as intermittent hypoxia, sleep fragmentation, and increase in autonomic tone. These disturbances have been associated with insulin resistance and type 2 diabetes mellitus (T2DM) in animal and human studies. Studies also suggest a bidirectional relationship between OSA and T2DM whereby T2DM itself might contribute to the features of OSA. Moreover, successful treatment of OSA may reduce these risks, although this is controversial. The purpose of this article is to review 1) the links and bidirectional associations between OSA and T2DM; 2) the pathogenic mechanisms that might link these two disease states; 3) the role of continuous positive airway pressure therapy in improving glucose tolerance, sensitivity, and resistance; and 4) the implications for clinical practice. Keywords: Insulin resistance, metabolic syndrome, sleep disordered breathing, intermittent hypoxia
format	article
author	Rajan P Greenberg H
author_facet	Rajan P Greenberg H
author_sort	Rajan P
title	Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
title_short	Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
title_full	Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
title_fullStr	Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
title_full_unstemmed	Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
title_sort	obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/a55750ab71bc4518922579836c847852
work_keys_str_mv	AT rajanp obstructivesleepapneaasariskfactorfortype2diabetesmellitus AT greenbergh obstructivesleepapneaasariskfactorfortype2diabetesmellitus
_version_	1718402242876276736

Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus

Ejemplares similares