Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions

Ripamonti et al. provide mechanistic insight into the contribution of individual Paxillin LIM domains in targeting and maintaining the structural integrity of focal adhesions (FAs). They show that mechanical coupling of paxillin in the FA to the plasma membrane or integrin is important for FA stabil...

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Autores principales:	Marta Ripamonti, Nicolas Liaudet, Latifeh Azizi, Daniel Bouvard, Vesa P. Hytönen, Bernhard Wehrle-Haller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a558e07f6d3d49de97381a3839425b85
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spelling	oai:doaj.org-article:a558e07f6d3d49de97381a3839425b852021-12-02T14:25:09ZStructural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions10.1038/s42003-021-01886-92399-3642https://doaj.org/article/a558e07f6d3d49de97381a3839425b852021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01886-9https://doaj.org/toc/2399-3642Ripamonti et al. provide mechanistic insight into the contribution of individual Paxillin LIM domains in targeting and maintaining the structural integrity of focal adhesions (FAs). They show that mechanical coupling of paxillin in the FA to the plasma membrane or integrin is important for FA stability and integrin-talin linkage.Marta RipamontiNicolas LiaudetLatifeh AziziDaniel BouvardVesa P. HytönenBernhard Wehrle-HallerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marta Ripamonti Nicolas Liaudet Latifeh Azizi Daniel Bouvard Vesa P. Hytönen Bernhard Wehrle-Haller Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
description	Ripamonti et al. provide mechanistic insight into the contribution of individual Paxillin LIM domains in targeting and maintaining the structural integrity of focal adhesions (FAs). They show that mechanical coupling of paxillin in the FA to the plasma membrane or integrin is important for FA stability and integrin-talin linkage.
format	article
author	Marta Ripamonti Nicolas Liaudet Latifeh Azizi Daniel Bouvard Vesa P. Hytönen Bernhard Wehrle-Haller
author_facet	Marta Ripamonti Nicolas Liaudet Latifeh Azizi Daniel Bouvard Vesa P. Hytönen Bernhard Wehrle-Haller
author_sort	Marta Ripamonti
title	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
title_short	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
title_full	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
title_fullStr	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
title_full_unstemmed	Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
title_sort	structural and functional analysis of lim domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a558e07f6d3d49de97381a3839425b85
work_keys_str_mv	AT martaripamonti structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions AT nicolasliaudet structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions AT latifehazizi structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions AT danielbouvard structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions AT vesaphytonen structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions AT bernhardwehrlehaller structuralandfunctionalanalysisoflimdomaindependentrecruitmentofpaxillintoavb3integrinpositivefocaladhesions
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Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions

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