PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

PARP1, in addition to its role in DNA repair, has a role in regulating gene transcription via PARylation of target proteins. Here the authors show that HuR is targeted after lipopolysaccharide exposure to regulate the inflammatory gene expression at post-transcriptional level.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yueshuang Ke, Yanlong Han, Xiaolan Guo, Jitao Wen, Ke Wang, Xue Jiang, Xue Tian, Xueqing Ba, Istvan Boldogh, Xianlu Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a55d7a2a75e7444fa4ab121ed3fd3490
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a55d7a2a75e7444fa4ab121ed3fd3490
record_format	dspace
spelling	oai:doaj.org-article:a55d7a2a75e7444fa4ab121ed3fd34902021-12-02T17:06:07ZPARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR10.1038/ncomms146322041-1723https://doaj.org/article/a55d7a2a75e7444fa4ab121ed3fd34902017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14632https://doaj.org/toc/2041-1723PARP1, in addition to its role in DNA repair, has a role in regulating gene transcription via PARylation of target proteins. Here the authors show that HuR is targeted after lipopolysaccharide exposure to regulate the inflammatory gene expression at post-transcriptional level.Yueshuang KeYanlong HanXiaolan GuoJitao WenKe WangXue JiangXue TianXueqing BaIstvan BoldoghXianlu ZengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yueshuang Ke Yanlong Han Xiaolan Guo Jitao Wen Ke Wang Xue Jiang Xue Tian Xueqing Ba Istvan Boldogh Xianlu Zeng PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
description	PARP1, in addition to its role in DNA repair, has a role in regulating gene transcription via PARylation of target proteins. Here the authors show that HuR is targeted after lipopolysaccharide exposure to regulate the inflammatory gene expression at post-transcriptional level.
format	article
author	Yueshuang Ke Yanlong Han Xiaolan Guo Jitao Wen Ke Wang Xue Jiang Xue Tian Xueqing Ba Istvan Boldogh Xianlu Zeng
author_facet	Yueshuang Ke Yanlong Han Xiaolan Guo Jitao Wen Ke Wang Xue Jiang Xue Tian Xueqing Ba Istvan Boldogh Xianlu Zeng
author_sort	Yueshuang Ke
title	PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
title_short	PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
title_full	PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
title_fullStr	PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
title_full_unstemmed	PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
title_sort	parp1 promotes gene expression at the post-transcriptional level by modulating the rna-binding protein hur
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a55d7a2a75e7444fa4ab121ed3fd3490
work_keys_str_mv	AT yueshuangke parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT yanlonghan parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT xiaolanguo parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT jitaowen parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT kewang parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT xuejiang parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT xuetian parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT xueqingba parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT istvanboldogh parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur AT xianluzeng parp1promotesgeneexpressionattheposttranscriptionallevelbymodulatingthernabindingproteinhur
_version_	1718381748753006592

PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Ejemplares similares