PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

PARP1, in addition to its role in DNA repair, has a role in regulating gene transcription via PARylation of target proteins. Here the authors show that HuR is targeted after lipopolysaccharide exposure to regulate the inflammatory gene expression at post-transcriptional level.

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Autores principales: Yueshuang Ke, Yanlong Han, Xiaolan Guo, Jitao Wen, Ke Wang, Xue Jiang, Xue Tian, Xueqing Ba, Istvan Boldogh, Xianlu Zeng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/a55d7a2a75e7444fa4ab121ed3fd3490
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