Whey-Derived Peptides at the Heart of the COVID-19 Pandemic

The renin–angiotensin system (RAS) is a key regulator of blood pressure and hypertension. Angiotensin-converting enzyme 2 (ACE2) and angiotensin-converting enzyme I (ACE) are two main components of the RAS that play a major role in blood pressure homeostasis. The severe acute respiratory syndrome co...

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Autores principales:	Yara Chamata, Kim G. Jackson, Kimberly A. Watson, Paula Jauregi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	whey peptides molecular docking hypertension ACE2 COVID-19 ACE inhibitory activity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a5639bdcaeb64500bf38cedbe259c4f3
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id	oai:doaj.org-article:a5639bdcaeb64500bf38cedbe259c4f3
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spelling	oai:doaj.org-article:a5639bdcaeb64500bf38cedbe259c4f32021-11-11T17:07:52ZWhey-Derived Peptides at the Heart of the COVID-19 Pandemic10.3390/ijms2221116621422-00671661-6596https://doaj.org/article/a5639bdcaeb64500bf38cedbe259c4f32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11662https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The renin–angiotensin system (RAS) is a key regulator of blood pressure and hypertension. Angiotensin-converting enzyme 2 (ACE2) and angiotensin-converting enzyme I (ACE) are two main components of the RAS that play a major role in blood pressure homeostasis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses ACE2 as a receptor to enter cells. Despite some controversies, numerous studies have reported a significant association between the use of ACE inhibitors and reduced risk of COVID-19. In our previous studies, we produced and identified peptide sequences present in whey hydrolysates exhibiting high ACE inhibitory activity. Therefore, the aim of this work is to obtain an improved understanding of the function of these natural peptides as RAS inhibitors and investigate their potential therapeutic role in the COVID-19 pandemic. The molecular interactions between peptides IPP, LIVTQ, IIAE, LVYPFP, and human ACE2 were assessed by employing a molecular docking approach. The results show that natural whey-derived peptides have a dual inhibitory action against both ACE and ACE2. This dual activity distinguishes these ACE inhibitory peptides from synthetic drugs, such as Captopril and Lisinopril which were not shown to inhibit ACE2 activity, and may represent a potential strategy in the treatment of COVID-19.Yara ChamataKim G. JacksonKimberly A. WatsonPaula JauregiMDPI AGarticlewhey peptidesmolecular dockinghypertensionACE2COVID-19ACE inhibitory activityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11662, p 11662 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	whey peptides molecular docking hypertension ACE2 COVID-19 ACE inhibitory activity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	whey peptides molecular docking hypertension ACE2 COVID-19 ACE inhibitory activity Biology (General) QH301-705.5 Chemistry QD1-999 Yara Chamata Kim G. Jackson Kimberly A. Watson Paula Jauregi Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
description	The renin–angiotensin system (RAS) is a key regulator of blood pressure and hypertension. Angiotensin-converting enzyme 2 (ACE2) and angiotensin-converting enzyme I (ACE) are two main components of the RAS that play a major role in blood pressure homeostasis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses ACE2 as a receptor to enter cells. Despite some controversies, numerous studies have reported a significant association between the use of ACE inhibitors and reduced risk of COVID-19. In our previous studies, we produced and identified peptide sequences present in whey hydrolysates exhibiting high ACE inhibitory activity. Therefore, the aim of this work is to obtain an improved understanding of the function of these natural peptides as RAS inhibitors and investigate their potential therapeutic role in the COVID-19 pandemic. The molecular interactions between peptides IPP, LIVTQ, IIAE, LVYPFP, and human ACE2 were assessed by employing a molecular docking approach. The results show that natural whey-derived peptides have a dual inhibitory action against both ACE and ACE2. This dual activity distinguishes these ACE inhibitory peptides from synthetic drugs, such as Captopril and Lisinopril which were not shown to inhibit ACE2 activity, and may represent a potential strategy in the treatment of COVID-19.
format	article
author	Yara Chamata Kim G. Jackson Kimberly A. Watson Paula Jauregi
author_facet	Yara Chamata Kim G. Jackson Kimberly A. Watson Paula Jauregi
author_sort	Yara Chamata
title	Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
title_short	Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
title_full	Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
title_fullStr	Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
title_full_unstemmed	Whey-Derived Peptides at the Heart of the COVID-19 Pandemic
title_sort	whey-derived peptides at the heart of the covid-19 pandemic
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a5639bdcaeb64500bf38cedbe259c4f3
work_keys_str_mv	AT yarachamata wheyderivedpeptidesattheheartofthecovid19pandemic AT kimgjackson wheyderivedpeptidesattheheartofthecovid19pandemic AT kimberlyawatson wheyderivedpeptidesattheheartofthecovid19pandemic AT paulajauregi wheyderivedpeptidesattheheartofthecovid19pandemic
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Whey-Derived Peptides at the Heart of the COVID-19 Pandemic

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