A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release

Hongxia Peng,1,2 Menglin Wang,1 Chuanyue Hu,1 Jun Guo1 1Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, Hunan University of Humanities, Science and Technology, Lou’di, Hunan, People’s Republic of China; 2State Key Laboratory of Powder Metallurgy and School...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peng H, Wang M, Hu C, Guo J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mgfe2o4@cus magnetic targeting nir light-electromagnetic wave heat conversion property dual controlled release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a56544c20eb640faa3febf8056442400
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a56544c20eb640faa3febf8056442400
record_format	dspace
spelling	oai:doaj.org-article:a56544c20eb640faa3febf80564424002021-12-02T12:28:38ZA New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release1178-2013https://doaj.org/article/a56544c20eb640faa3febf80564424002020-11-01T00:00:00Zhttps://www.dovepress.com/a-new-type-of-mgfe2o4cus-aptes-nanocarrier-for-magnetic-targeting-and--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hongxia Peng,1,2 Menglin Wang,1 Chuanyue Hu,1 Jun Guo1 1Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, Hunan University of Humanities, Science and Technology, Lou’di, Hunan, People’s Republic of China; 2State Key Laboratory of Powder Metallurgy and School of Materials Science and Engineering, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Hongxia Peng Tel/ Fax +86-1897511023Email penghongxia1@126.comJun Guo Email 961009854@qq.comIntroduction: Cancer is a major health problem worldwide, and the most extensive treatment can be obtained by using chemotherapy in the clinic. However, due to the low selectivity of cancer cells, chemotherapy drugs produce a series of grievous side effects on normal cells.Methods: In this research, we developed novel nanocarriers for magnetically targeted near-infrared (NIR) light-electromagnetic wave dual controlled drug delivery based on MgFe2O4@CuS nanoparticles (NPs) modified with aminopropyltriethoxysilane (APTES) in response to magnetic, NIR light, and electromagnetic wave irradiation. Synthesis and characterization of MgFe2O4@CuS-APTES NPs was carried out using X-ray diffraction measurements, scanning electron microscopy, transmission electron microscopy, photoluminescence emission spectra, UV-1800 spectrophotometer, N5230A vector network analyzer, MDS-6 microwave sample preparation system, and superconducting quantum interference device. In addition to that mentioned above, we also explored many other sides, such as the drug-loading, drug-controlled release efficiency, elect99omagnetic wave thermal effect and photo-thermal effect.Results: The results showed that APTES-modified MgFe2O4@CuS NPs had 37% high drug-loading capacity and high electromagnetic wave thermal conversion ability and NIR-light thermal conversion ability. In addition, ibuprofen (IBU) release from the MgFe2O4@CuS-APTES-IBU depends on the electromagnetic wave (2.45 GHz) and 1060 nm NIR light irradiation. After five cycles, the drug-release percentage was 90% and 66% separately, and could be adjusted by the time and cycles times of electromagnetic wave and NIR light irritation. Electromagnetic wave irradiation compared with NIR light irradiation, has a higher drug release rate and better penetration. Therefore, choosing different stimulation methods according to the treatment needs of the disease, we can achieve accurate personalized treatment of the disease.Discussion: Our findings indicate that multifunctional APTES modified MgFe2O4@CuS NPs could be used for the first time as a new drug carrier for “location-timing-quantification” drug release with magnetic targeting and dual control of NIR light-electromagnetic waves.Keywords: MgFe2O4@CuS, magnetic targeting, NIR light-electromagnetic wave heat conversion property, dual controlled releasePeng HWang MHu CGuo JDove Medical Pressarticlemgfe2o4@cusmagnetic targetingnir light-electromagnetic wave heat conversion propertydual controlled releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8783-8802 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mgfe2o4@cus magnetic targeting nir light-electromagnetic wave heat conversion property dual controlled release Medicine (General) R5-920
spellingShingle	mgfe2o4@cus magnetic targeting nir light-electromagnetic wave heat conversion property dual controlled release Medicine (General) R5-920 Peng H Wang M Hu C Guo J A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
description	Hongxia Peng,1,2 Menglin Wang,1 Chuanyue Hu,1 Jun Guo1 1Hunan Provincial Key Laboratory of Fine Ceramics and Powder Materials, Hunan University of Humanities, Science and Technology, Lou’di, Hunan, People’s Republic of China; 2State Key Laboratory of Powder Metallurgy and School of Materials Science and Engineering, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence: Hongxia Peng Tel/ Fax +86-1897511023Email penghongxia1@126.comJun Guo Email 961009854@qq.comIntroduction: Cancer is a major health problem worldwide, and the most extensive treatment can be obtained by using chemotherapy in the clinic. However, due to the low selectivity of cancer cells, chemotherapy drugs produce a series of grievous side effects on normal cells.Methods: In this research, we developed novel nanocarriers for magnetically targeted near-infrared (NIR) light-electromagnetic wave dual controlled drug delivery based on MgFe2O4@CuS nanoparticles (NPs) modified with aminopropyltriethoxysilane (APTES) in response to magnetic, NIR light, and electromagnetic wave irradiation. Synthesis and characterization of MgFe2O4@CuS-APTES NPs was carried out using X-ray diffraction measurements, scanning electron microscopy, transmission electron microscopy, photoluminescence emission spectra, UV-1800 spectrophotometer, N5230A vector network analyzer, MDS-6 microwave sample preparation system, and superconducting quantum interference device. In addition to that mentioned above, we also explored many other sides, such as the drug-loading, drug-controlled release efficiency, elect99omagnetic wave thermal effect and photo-thermal effect.Results: The results showed that APTES-modified MgFe2O4@CuS NPs had 37% high drug-loading capacity and high electromagnetic wave thermal conversion ability and NIR-light thermal conversion ability. In addition, ibuprofen (IBU) release from the MgFe2O4@CuS-APTES-IBU depends on the electromagnetic wave (2.45 GHz) and 1060 nm NIR light irradiation. After five cycles, the drug-release percentage was 90% and 66% separately, and could be adjusted by the time and cycles times of electromagnetic wave and NIR light irritation. Electromagnetic wave irradiation compared with NIR light irradiation, has a higher drug release rate and better penetration. Therefore, choosing different stimulation methods according to the treatment needs of the disease, we can achieve accurate personalized treatment of the disease.Discussion: Our findings indicate that multifunctional APTES modified MgFe2O4@CuS NPs could be used for the first time as a new drug carrier for “location-timing-quantification” drug release with magnetic targeting and dual control of NIR light-electromagnetic waves.Keywords: MgFe2O4@CuS, magnetic targeting, NIR light-electromagnetic wave heat conversion property, dual controlled release
format	article
author	Peng H Wang M Hu C Guo J
author_facet	Peng H Wang M Hu C Guo J
author_sort	Peng H
title	A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
title_short	A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
title_full	A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
title_fullStr	A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
title_full_unstemmed	A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release
title_sort	new type of mgfe2o4@cus-aptes nanocarrier for magnetic targeting and light-microwave dual controlled drug release
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/a56544c20eb640faa3febf8056442400
work_keys_str_mv	AT pengh anewtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT wangm anewtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT huc anewtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT guoj anewtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT pengh newtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT wangm newtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT huc newtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease AT guoj newtypeofmgfe2o4cusaptesnanocarrierformagnetictargetingandlightmicrowavedualcontrolleddrugrelease
_version_	1718394470496468992

A New Type of MgFe2O4@CuS-APTES Nanocarrier for Magnetic Targeting and Light-Microwave Dual Controlled Drug Release

Ejemplares similares