Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men

Background: Not only low-density lipoprotein (LDL) cholesterol but also non-high-density lipoprotein cholesterol (non-HDL-C), very low-density lipoprotein (VLDL) cholesterol (VLDL-C), and intermediate-density lipoprotein (IDL) cholesterol (IDL-C) are reported to be significant risk markers for coron...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroshi Yoshida, Kumie Ito, Daisuke Manita, Ryo Sato, Chika Hiraishi, Sadako Matsui, Yuji Hirowatari
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Framingham risk score IDL-cholesterol Non-HDL cholesterol VLDL-cholesterol Suita score Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/a567fe1be9734ca7a0c06e0c5deca449
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a567fe1be9734ca7a0c06e0c5deca449
record_format	dspace
spelling	oai:doaj.org-article:a567fe1be9734ca7a0c06e0c5deca4492021-11-22T05:02:22ZClinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men2297-055X10.3389/fcvm.2021.756057https://doaj.org/article/a567fe1be9734ca7a0c06e0c5deca4492021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.756057/fullhttps://doaj.org/toc/2297-055XBackground: Not only low-density lipoprotein (LDL) cholesterol but also non-high-density lipoprotein cholesterol (non-HDL-C), very low-density lipoprotein (VLDL) cholesterol (VLDL-C), and intermediate-density lipoprotein (IDL) cholesterol (IDL-C) are reported to be significant risk markers for coronary heart disease (CHD). We reported the relevance of IDL-C to Framingham risk score (F-score), but the present study addressed the relevance of IDL-C to Suita score (S-score), a risk score for coronary heart disease (CHD) developed for the Japanese individuals in addition to F-score.Methods: The cholesterol levels of lipoproteins, including triglyceride (TG)-rich lipoproteins (IDL and VLDL), were measured by an anion exchange high-performance liquid chromatography (AEX-HPLC). This study enrolled 476 men, aged mean 51 years and free of CHD and stroke.Results: Non-HDL-C, IDL-C, and VLDL-C significantly correlated with F-score and S-score. In the multiple stepwise regression analysis, IDL-C as well as body mass index (BMI) significantly correlated with both F-score and S-score in both the total subjects and the subjects without drug therapy. The multivariate logistic analysis with the model composed of BMI and IDL-C as the predictor variables demonstrated that 1 SD increase in IDL-C was an independent predictor for 10-year CHD risk >10% of F-score (OR 1.534, 95% CI 1.266–1.859, p < 0001) and that of S-score (OR 1.372, 95% CI 1.130–1.667, p = 0.0014) in the total subjects. Even in the subjects without the drug therapy, the increased IDL-C, as well as BMI, were significant predictors for 10-year CHD risk >10% of S-score as well as F-score.Conclusion: These results suggest the significant relevance of the increased IDL-C for CHD risk scores in middle-aged men free of CHD and stroke. Further investigations are needed in women and elderly subjects.Hiroshi YoshidaHiroshi YoshidaKumie ItoDaisuke ManitaRyo SatoChika HiraishiSadako MatsuiYuji HirowatariFrontiers Media S.A.articleFramingham risk scoreIDL-cholesterolNon-HDL cholesterolVLDL-cholesterolSuita scoreDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Framingham risk score IDL-cholesterol Non-HDL cholesterol VLDL-cholesterol Suita score Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Framingham risk score IDL-cholesterol Non-HDL cholesterol VLDL-cholesterol Suita score Diseases of the circulatory (Cardiovascular) system RC666-701 Hiroshi Yoshida Hiroshi Yoshida Kumie Ito Daisuke Manita Ryo Sato Chika Hiraishi Sadako Matsui Yuji Hirowatari Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
description	Background: Not only low-density lipoprotein (LDL) cholesterol but also non-high-density lipoprotein cholesterol (non-HDL-C), very low-density lipoprotein (VLDL) cholesterol (VLDL-C), and intermediate-density lipoprotein (IDL) cholesterol (IDL-C) are reported to be significant risk markers for coronary heart disease (CHD). We reported the relevance of IDL-C to Framingham risk score (F-score), but the present study addressed the relevance of IDL-C to Suita score (S-score), a risk score for coronary heart disease (CHD) developed for the Japanese individuals in addition to F-score.Methods: The cholesterol levels of lipoproteins, including triglyceride (TG)-rich lipoproteins (IDL and VLDL), were measured by an anion exchange high-performance liquid chromatography (AEX-HPLC). This study enrolled 476 men, aged mean 51 years and free of CHD and stroke.Results: Non-HDL-C, IDL-C, and VLDL-C significantly correlated with F-score and S-score. In the multiple stepwise regression analysis, IDL-C as well as body mass index (BMI) significantly correlated with both F-score and S-score in both the total subjects and the subjects without drug therapy. The multivariate logistic analysis with the model composed of BMI and IDL-C as the predictor variables demonstrated that 1 SD increase in IDL-C was an independent predictor for 10-year CHD risk >10% of F-score (OR 1.534, 95% CI 1.266–1.859, p < 0001) and that of S-score (OR 1.372, 95% CI 1.130–1.667, p = 0.0014) in the total subjects. Even in the subjects without the drug therapy, the increased IDL-C, as well as BMI, were significant predictors for 10-year CHD risk >10% of S-score as well as F-score.Conclusion: These results suggest the significant relevance of the increased IDL-C for CHD risk scores in middle-aged men free of CHD and stroke. Further investigations are needed in women and elderly subjects.
format	article
author	Hiroshi Yoshida Hiroshi Yoshida Kumie Ito Daisuke Manita Ryo Sato Chika Hiraishi Sadako Matsui Yuji Hirowatari
author_facet	Hiroshi Yoshida Hiroshi Yoshida Kumie Ito Daisuke Manita Ryo Sato Chika Hiraishi Sadako Matsui Yuji Hirowatari
author_sort	Hiroshi Yoshida
title	Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
title_short	Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
title_full	Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
title_fullStr	Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
title_full_unstemmed	Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men
title_sort	clinical significance of intermediate-density lipoprotein cholesterol determination as a predictor for coronary heart disease risk in middle-aged men
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a567fe1be9734ca7a0c06e0c5deca449
work_keys_str_mv	AT hiroshiyoshida clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT hiroshiyoshida clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT kumieito clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT daisukemanita clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT ryosato clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT chikahiraishi clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT sadakomatsui clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen AT yujihirowatari clinicalsignificanceofintermediatedensitylipoproteincholesteroldeterminationasapredictorforcoronaryheartdiseaseriskinmiddleagedmen
_version_	1718418179134324736

Clinical Significance of Intermediate-Density Lipoprotein Cholesterol Determination as a Predictor for Coronary Heart Disease Risk in Middle-Aged Men

Ejemplares similares