The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals

The results of a toxicological study of isopropyl meta-carborane with its repeated (chronic) administration to rats, mainly in the form of inhalations, are presented for the first time to fill in the missing information on the toxicology of carboranes that have found wide application in various fiel...

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Autores principales:	G. G. Yushkov, V. V. Igumenshcheva, T. M. Filippova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	organic compounds of boron isopropyl meta-carborane toxicological studies experiment Science Q
Acceso en línea:	https://doaj.org/article/a574b9698b4f4339a250209eb0191a86
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spelling	oai:doaj.org-article:a574b9698b4f4339a250209eb0191a862021-11-23T06:14:40ZThe results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals2541-94202587-959610.29413/ABS.2018-3.2.20https://doaj.org/article/a574b9698b4f4339a250209eb0191a862018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/570https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The results of a toxicological study of isopropyl meta-carborane with its repeated (chronic) administration to rats, mainly in the form of inhalations, are presented for the first time to fill in the missing information on the toxicology of carboranes that have found wide application in various fields of human economic activity. The aim of the study was to identify the characteristic features of the organism's response to repeated exposure to the substance, as well as the possible specificity inherent in boron compounds. Methods. Along with numerous typical methods of preventive toxicology (physiological, hematological, biochemical, morphological), the methods for evaluation of possible mutagenic (dominant lethal mutations, chromosomal aberrations) of gonadotoxic and embryotoxic effects were used. Statistical processing of data was carried out using the programs "Microsoft Office Excel 2007" and "Biostat". Differences were considered statistically significant at p < 0.05, using a parametric test. Results. The conducted investigations established signs of the toxic effect of the substance, mainly at the level of high concentrations, with a change in behavioral responses and against this background, an increase in the activity of ATPase and a decrease in SDGase activity in the brain homogenate, as well as hematological (anemia, phagocytosis), biochemical (increased catalase activity, ALT activity in liver homogenate and serum levels), physiological (increase in oxygen consumption) and pathological parameters. At the same levels of exposure, an increase in postimplantation death of embryos, a decrease in the motility of spermatozoa, a decrease in the ability of females to survive live embryos were found. Conclusion. On the basis of the data obtained, isopropyl meta-carborane is classified as polytropic, but under conditions of multiple (chronic) inhalation administration to animals with a pronounced gonadotoxic effect that does not appear when exposed to a concentration of 3 mg/m3.G. G. YushkovV. V. IgumenshchevaT. M. FilippovaScientific Сentre for Family Health and Human Reproduction Problemsarticleorganic compounds of boronisopropyl meta-carboranetoxicological studiesexperimentScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 111-115 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	organic compounds of boron isopropyl meta-carborane toxicological studies experiment Science Q
spellingShingle	organic compounds of boron isopropyl meta-carborane toxicological studies experiment Science Q G. G. Yushkov V. V. Igumenshcheva T. M. Filippova The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
description	The results of a toxicological study of isopropyl meta-carborane with its repeated (chronic) administration to rats, mainly in the form of inhalations, are presented for the first time to fill in the missing information on the toxicology of carboranes that have found wide application in various fields of human economic activity. The aim of the study was to identify the characteristic features of the organism's response to repeated exposure to the substance, as well as the possible specificity inherent in boron compounds. Methods. Along with numerous typical methods of preventive toxicology (physiological, hematological, biochemical, morphological), the methods for evaluation of possible mutagenic (dominant lethal mutations, chromosomal aberrations) of gonadotoxic and embryotoxic effects were used. Statistical processing of data was carried out using the programs "Microsoft Office Excel 2007" and "Biostat". Differences were considered statistically significant at p < 0.05, using a parametric test. Results. The conducted investigations established signs of the toxic effect of the substance, mainly at the level of high concentrations, with a change in behavioral responses and against this background, an increase in the activity of ATPase and a decrease in SDGase activity in the brain homogenate, as well as hematological (anemia, phagocytosis), biochemical (increased catalase activity, ALT activity in liver homogenate and serum levels), physiological (increase in oxygen consumption) and pathological parameters. At the same levels of exposure, an increase in postimplantation death of embryos, a decrease in the motility of spermatozoa, a decrease in the ability of females to survive live embryos were found. Conclusion. On the basis of the data obtained, isopropyl meta-carborane is classified as polytropic, but under conditions of multiple (chronic) inhalation administration to animals with a pronounced gonadotoxic effect that does not appear when exposed to a concentration of 3 mg/m3.
format	article
author	G. G. Yushkov V. V. Igumenshcheva T. M. Filippova
author_facet	G. G. Yushkov V. V. Igumenshcheva T. M. Filippova
author_sort	G. G. Yushkov
title	The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
title_short	The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
title_full	The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
title_fullStr	The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
title_full_unstemmed	The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
title_sort	results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/a574b9698b4f4339a250209eb0191a86
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The results of a toxicological study of isopropyl meta-carborane with its multiple (chronic) intake into the body of laboratory animals

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