Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

Abstract Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gast...

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Autores principales:	Enrico Gugliandolo, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Rosalba Siracusa, Tiziana Genovese, Ramona D’Amico, Daniela Impellizzeri, Rosanna Di Paola, Salvatore Cuzzocrea, Rosalia Crupi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a576c4dcb1234967ba6141ac71d138aa
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spelling	oai:doaj.org-article:a576c4dcb1234967ba6141ac71d138aa2021-12-02T14:11:30ZProtective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice10.1038/s41598-021-83170-82045-2322https://doaj.org/article/a576c4dcb1234967ba6141ac71d138aa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83170-8https://doaj.org/toc/2045-2322Abstract Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.Enrico GugliandoloMarika CordaroRoberta FuscoAlessio Filippo PeritoreRosalba SiracusaTiziana GenoveseRamona D’AmicoDaniela ImpellizzeriRosanna Di PaolaSalvatore CuzzocreaRosalia CrupiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrico Gugliandolo Marika Cordaro Roberta Fusco Alessio Filippo Peritore Rosalba Siracusa Tiziana Genovese Ramona D’Amico Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
description	Abstract Gastric ulcer or peptic ulcer is a common disease worldwide. Basically, it develops when there is an imbalance between the protective and aggressive factors, especially at the luminal surface of epithelial cells. Thus, there is a constant interest in research new drugs for treatment of gastric ulcer. The snail secretion is a dense mucous, that covers the external surface of the snails, with important functions for the survival of snails. The biological proprieties of snail Helix Aspersa Muller mucus it has been known for centuries to treat human disorders in particular for skin disease. Recently the use of snail mucus has seen a worldwide increase, as a component in cosmetic product and it has been used in particular for the management of wound and skin disorders. In this study we use a murine model of ethanol intragastric administration which has been widely used to test the drugs efficacies and to explore the underlying mechanism for gastric ulcer development. The intragastric ethanol administration causes several mucosal damages and an induction of a severe inflammatory response. Our results show a significant protective effect of snail secretion filtrate in reducing macroscopic and histological lesions, as well the protective effect on mucus content, oxidative stress and inflammatory response. In conclusion this study demonstrate the protective effect of intragastrical snail secretion filtrate, in a model of ethanol-induced gastric ulcer in mice, suggesting its possible useful use in the treatment or prevention of gastric ulcer.
format	article
author	Enrico Gugliandolo Marika Cordaro Roberta Fusco Alessio Filippo Peritore Rosalba Siracusa Tiziana Genovese Ramona D’Amico Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi
author_facet	Enrico Gugliandolo Marika Cordaro Roberta Fusco Alessio Filippo Peritore Rosalba Siracusa Tiziana Genovese Ramona D’Amico Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi
author_sort	Enrico Gugliandolo
title	Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
title_short	Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
title_full	Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
title_fullStr	Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
title_full_unstemmed	Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
title_sort	protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a576c4dcb1234967ba6141ac71d138aa
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Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice

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