A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.

A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.

<h4>Objective</h4>To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI.<h4>Methods</h4>In a population-base...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ola Nordqvist, Olof Björneld, Lars Brudin, Pär Wanby, Rebecca Nobin, Martin Carlsson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a5835f32e2064b60a2953e541f115088
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a5835f32e2064b60a2953e541f115088
record_format dspace
spelling oai:doaj.org-article:a5835f32e2064b60a2953e541f1150882021-12-02T20:17:34ZA novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.1932-620310.1371/journal.pone.0256093https://doaj.org/article/a5835f32e2064b60a2953e541f1150882021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256093https://doaj.org/toc/1932-6203<h4>Objective</h4>To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI.<h4>Methods</h4>In a population-based retrospective open cohort study we used real world data from the Electronic Health Register (EHR) in Region Kalmar County, Sweden. 23 209 patients prescribed AEDs at any time from January 2008 to November 2018 and 23 281 matching controls were followed from first registration in the EHR until the first documented LEF, disenrollment (or death) or until the end of the study period, whichever came first. Risks of LEF measured as hazard rate ratios in relation to the suggested risk factors and in comparison to matched controls were analyzed using Cox regression. The index was developed using a linear combination of the statistically significant variables multiplied by the corresponding regression coefficients.<h4>Results</h4>Data from 23 209 patients prescribed AEDs and 2084 documented LEFs during a follow-up time of more than 10 years resulted in the Kalmar Epilepsy Fracture Risk Index (KEFRI). KEFRI = Age-category x (1.18) + Gender x (-0.51) + AED-type x (0.29) + Epilepsy diagnosis-category x (0.31) + BMI-category x (-0.35). All five previously suggested risk factors were confirmed. Women aged 75 years and older treated with an inducing AED against epilepsy and BMIs of 25 kg/m2 or below had 48 times higher LEF rates compared to men aged 50 years or younger, treated with a non-inducing AED for a condition other than epilepsy and BMIs above 25 kg/m2.<h4>Conclusion</h4>The KEFRI is the first weighted multifactorial assessment tool estimating risks of LEF in patients prescribed AEDs and could serve as a feasible guide within clinical practice.Ola NordqvistOlof BjörneldLars BrudinPär WanbyRebecca NobinMartin CarlssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256093 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ola Nordqvist
Olof Björneld
Lars Brudin
Pär Wanby
Rebecca Nobin
Martin Carlsson
A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
description <h4>Objective</h4>To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI.<h4>Methods</h4>In a population-based retrospective open cohort study we used real world data from the Electronic Health Register (EHR) in Region Kalmar County, Sweden. 23 209 patients prescribed AEDs at any time from January 2008 to November 2018 and 23 281 matching controls were followed from first registration in the EHR until the first documented LEF, disenrollment (or death) or until the end of the study period, whichever came first. Risks of LEF measured as hazard rate ratios in relation to the suggested risk factors and in comparison to matched controls were analyzed using Cox regression. The index was developed using a linear combination of the statistically significant variables multiplied by the corresponding regression coefficients.<h4>Results</h4>Data from 23 209 patients prescribed AEDs and 2084 documented LEFs during a follow-up time of more than 10 years resulted in the Kalmar Epilepsy Fracture Risk Index (KEFRI). KEFRI = Age-category x (1.18) + Gender x (-0.51) + AED-type x (0.29) + Epilepsy diagnosis-category x (0.31) + BMI-category x (-0.35). All five previously suggested risk factors were confirmed. Women aged 75 years and older treated with an inducing AED against epilepsy and BMIs of 25 kg/m2 or below had 48 times higher LEF rates compared to men aged 50 years or younger, treated with a non-inducing AED for a condition other than epilepsy and BMIs above 25 kg/m2.<h4>Conclusion</h4>The KEFRI is the first weighted multifactorial assessment tool estimating risks of LEF in patients prescribed AEDs and could serve as a feasible guide within clinical practice.
format article
author Ola Nordqvist
Olof Björneld
Lars Brudin
Pär Wanby
Rebecca Nobin
Martin Carlsson
author_facet Ola Nordqvist
Olof Björneld
Lars Brudin
Pär Wanby
Rebecca Nobin
Martin Carlsson
author_sort Ola Nordqvist
title A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
title_short A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
title_full A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
title_fullStr A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
title_full_unstemmed A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
title_sort novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/a5835f32e2064b60a2953e541f115088
work_keys_str_mv AT olanordqvist anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT olofbjorneld anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT larsbrudin anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT parwanby anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT rebeccanobin anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT martincarlsson anovelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT olanordqvist novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT olofbjorneld novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT larsbrudin novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT parwanby novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT rebeccanobin novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
AT martincarlsson novelindextoassesslowenergyfracturerisksinpatientsprescribedantiepilepticdrugs
_version_ 1718374364052717568

Ejemplares similares