Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study

PurposePathology reviews for upper urinary tract cancer (UTUC) remained scarce in the literature. Here, we reported the interobserver variation among the review and local pathologies of featured histologic characteristics for UTUC.MethodsPatients who underwent definitive surgical treatments for UTUC...

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Autores principales:	Chia-Hui Chang, Wen-Jeng Wu, Hsiang-Ying Lee, Chih-Hung Lin, Chung-Tai Yue, Yuan-Hong Jiang, Yu-Khun Lee, Kuan Hsun Huang, Yao Chou Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	upper urinary tract cancer variant histology pathology review intratubular spread interobserver agreement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a58ea0d63b5042c29dbc4e7a0a84993d
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spelling	oai:doaj.org-article:a58ea0d63b5042c29dbc4e7a0a84993d2021-11-30T23:43:03ZImpact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study2234-943X10.3389/fonc.2021.757359https://doaj.org/article/a58ea0d63b5042c29dbc4e7a0a84993d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.757359/fullhttps://doaj.org/toc/2234-943XPurposePathology reviews for upper urinary tract cancer (UTUC) remained scarce in the literature. Here, we reported the interobserver variation among the review and local pathologies of featured histologic characteristics for UTUC.MethodsPatients who underwent definitive surgical treatments for UTUC were retrospectively reviewed for eligibility of pathology review. In the Taiwan UTUC Collaboration cohort, 212 cases were reviewed, of which 154 cases were eligible for pathology review. Agreement between original pathology and review pathology was measured by the total percentage of agreement and by simple kappa statistics. The prognostic impact was analyzed by the Cox regression model with the estimation of hazard ratios (HR) and 95% confidence intervals.ResultsThere were 80 women and 74 men enrolled in this study, and the median age at treatment was 71.7 years. The agreement is moderate agreement for surgical margin status (87.7%; κ = 0.61), tumor grade (82.5%; κ = 0.43), tumor invasiveness (76.6%; κ = 0.45), lymphovascular invasion (70.8%; κ = 0.42) and T stage (67.5%; κ = 0.52). The interobserver agreements for perineural invasion and variant histology identification were slight. Kaplan–Meier analysis for disease-free survival revealed comparable results in local and review pathology for localized (Tis, Ta, T1–2) or advanced T stage (T3–4).ConclusionsPathology review of UTUC had minimal impact on clinical practice based on current available disease treatment guidelines. However, significant interobserver variations were observed in featured adverse histopathological characters.Chia-Hui ChangWen-Jeng WuWen-Jeng WuWen-Jeng WuHsiang-Ying LeeHsiang-Ying LeeHsiang-Ying LeeChih-Hung LinChih-Hung LinChung-Tai YueChung-Tai YueYuan-Hong JiangYu-Khun LeeKuan Hsun HuangYao Chou TsaiYao Chou TsaiYao Chou TsaiFrontiers Media S.A.articleupper urinary tract cancervariant histologypathology reviewintratubular spreadinterobserver agreementNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	upper urinary tract cancer variant histology pathology review intratubular spread interobserver agreement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	upper urinary tract cancer variant histology pathology review intratubular spread interobserver agreement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chia-Hui Chang Wen-Jeng Wu Wen-Jeng Wu Wen-Jeng Wu Hsiang-Ying Lee Hsiang-Ying Lee Hsiang-Ying Lee Chih-Hung Lin Chih-Hung Lin Chung-Tai Yue Chung-Tai Yue Yuan-Hong Jiang Yu-Khun Lee Kuan Hsun Huang Yao Chou Tsai Yao Chou Tsai Yao Chou Tsai Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
description	PurposePathology reviews for upper urinary tract cancer (UTUC) remained scarce in the literature. Here, we reported the interobserver variation among the review and local pathologies of featured histologic characteristics for UTUC.MethodsPatients who underwent definitive surgical treatments for UTUC were retrospectively reviewed for eligibility of pathology review. In the Taiwan UTUC Collaboration cohort, 212 cases were reviewed, of which 154 cases were eligible for pathology review. Agreement between original pathology and review pathology was measured by the total percentage of agreement and by simple kappa statistics. The prognostic impact was analyzed by the Cox regression model with the estimation of hazard ratios (HR) and 95% confidence intervals.ResultsThere were 80 women and 74 men enrolled in this study, and the median age at treatment was 71.7 years. The agreement is moderate agreement for surgical margin status (87.7%; κ = 0.61), tumor grade (82.5%; κ = 0.43), tumor invasiveness (76.6%; κ = 0.45), lymphovascular invasion (70.8%; κ = 0.42) and T stage (67.5%; κ = 0.52). The interobserver agreements for perineural invasion and variant histology identification were slight. Kaplan–Meier analysis for disease-free survival revealed comparable results in local and review pathology for localized (Tis, Ta, T1–2) or advanced T stage (T3–4).ConclusionsPathology review of UTUC had minimal impact on clinical practice based on current available disease treatment guidelines. However, significant interobserver variations were observed in featured adverse histopathological characters.
format	article
author	Chia-Hui Chang Wen-Jeng Wu Wen-Jeng Wu Wen-Jeng Wu Hsiang-Ying Lee Hsiang-Ying Lee Hsiang-Ying Lee Chih-Hung Lin Chih-Hung Lin Chung-Tai Yue Chung-Tai Yue Yuan-Hong Jiang Yu-Khun Lee Kuan Hsun Huang Yao Chou Tsai Yao Chou Tsai Yao Chou Tsai
author_facet	Chia-Hui Chang Wen-Jeng Wu Wen-Jeng Wu Wen-Jeng Wu Hsiang-Ying Lee Hsiang-Ying Lee Hsiang-Ying Lee Chih-Hung Lin Chih-Hung Lin Chung-Tai Yue Chung-Tai Yue Yuan-Hong Jiang Yu-Khun Lee Kuan Hsun Huang Yao Chou Tsai Yao Chou Tsai Yao Chou Tsai
author_sort	Chia-Hui Chang
title	Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
title_short	Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
title_full	Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
title_fullStr	Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
title_full_unstemmed	Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study
title_sort	impact of pathology review in adverse histological characteristics and pt stages of upper tract urothelial cancer in a multicenter study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a58ea0d63b5042c29dbc4e7a0a84993d
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Impact of Pathology Review in Adverse Histological Characteristics and pT Stages of Upper Tract Urothelial Cancer in a Multicenter Study

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