Synthesis, characterization and in vitro biological evaluation of two matrine derivatives

Abstract Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities. In present work, two matrine derivatives have been successfully synthesized via introducing indole and cyclohexylamino to 13 position of...

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Autores principales:	Xingan Cheng, Jingmin Ye, Huiqing He, Zhanmei Liu, Chunbao (Charles) Xu, Bo Wu, Xialing Xiong, Xugang Shu, Xuhong Jiang, Xiangjing Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Sophocarpine Insect Cells Matrine Treatment Human Cancer Cell Lines HeLa Apoptosis Bodies Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a59208487f8d4780b08694296fb6bb95
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spelling	oai:doaj.org-article:a59208487f8d4780b08694296fb6bb952021-12-02T15:07:57ZSynthesis, characterization and in vitro biological evaluation of two matrine derivatives10.1038/s41598-018-33908-82045-2322https://doaj.org/article/a59208487f8d4780b08694296fb6bb952018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33908-8https://doaj.org/toc/2045-2322Abstract Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities. In present work, two matrine derivatives have been successfully synthesized via introducing indole and cyclohexylamino to 13 position of matrine, respectively, with sophocarpine as starting material, and structurally characterized via infrared spectroscopy(IR), MS, 1 H NMR, 13 C NMR and X-ray crystal diffraction. The results of the in vitro biological activity tests showed that these two matrine derivatives exhibited even better activities against human cancer cells Hela229 and insect cell line Sf9 from Spodoptera frugiperda (J. E. Smith) than that of parent matrine, suggesting that the heterocyclic or cyclic group can dramatically increase the biological activity of matrine. It is worth to mention that 13-indole-matrine could possibly inhibit the growth of insect cells or human cancer cells by inducing cell apoptosis. The results of the present study provide useful information for further structural modifications of these compounds and for exploring new, potent anti-cancer agents and environment friendly pesticides.Xingan ChengJingmin YeHuiqing HeZhanmei LiuChunbao (Charles) XuBo WuXialing XiongXugang ShuXuhong JiangXiangjing QinNature PortfolioarticleSophocarpineInsect CellsMatrine TreatmentHuman Cancer Cell Lines HeLaApoptosis BodiesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sophocarpine Insect Cells Matrine Treatment Human Cancer Cell Lines HeLa Apoptosis Bodies Medicine R Science Q
spellingShingle	Sophocarpine Insect Cells Matrine Treatment Human Cancer Cell Lines HeLa Apoptosis Bodies Medicine R Science Q Xingan Cheng Jingmin Ye Huiqing He Zhanmei Liu Chunbao (Charles) Xu Bo Wu Xialing Xiong Xugang Shu Xuhong Jiang Xiangjing Qin Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
description	Abstract Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities. In present work, two matrine derivatives have been successfully synthesized via introducing indole and cyclohexylamino to 13 position of matrine, respectively, with sophocarpine as starting material, and structurally characterized via infrared spectroscopy(IR), MS, 1 H NMR, 13 C NMR and X-ray crystal diffraction. The results of the in vitro biological activity tests showed that these two matrine derivatives exhibited even better activities against human cancer cells Hela229 and insect cell line Sf9 from Spodoptera frugiperda (J. E. Smith) than that of parent matrine, suggesting that the heterocyclic or cyclic group can dramatically increase the biological activity of matrine. It is worth to mention that 13-indole-matrine could possibly inhibit the growth of insect cells or human cancer cells by inducing cell apoptosis. The results of the present study provide useful information for further structural modifications of these compounds and for exploring new, potent anti-cancer agents and environment friendly pesticides.
format	article
author	Xingan Cheng Jingmin Ye Huiqing He Zhanmei Liu Chunbao (Charles) Xu Bo Wu Xialing Xiong Xugang Shu Xuhong Jiang Xiangjing Qin
author_facet	Xingan Cheng Jingmin Ye Huiqing He Zhanmei Liu Chunbao (Charles) Xu Bo Wu Xialing Xiong Xugang Shu Xuhong Jiang Xiangjing Qin
author_sort	Xingan Cheng
title	Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
title_short	Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
title_full	Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
title_fullStr	Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
title_full_unstemmed	Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
title_sort	synthesis, characterization and in vitro biological evaluation of two matrine derivatives
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a59208487f8d4780b08694296fb6bb95
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Synthesis, characterization and in vitro biological evaluation of two matrine derivatives

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