Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System

Sensory systems have to be malleable to context-dependent modulations occurring over different time scales, in order to serve their evolutionary function of informing about the external world while also eliciting survival-promoting behaviors. Stress is a major context-dependent signal that can have...

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Autores principales:	Sara Pagella, Jan M. Deussing, Conny Kopp-Scheinpflug
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	urocortin CRFR2 auditory stress signaling multimodal volume transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a593ecf1ae644e6eb6e9473a8df3cf0f
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spelling	oai:doaj.org-article:a593ecf1ae644e6eb6e9473a8df3cf0f2021-11-12T07:01:05ZExpression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System1662-511010.3389/fncir.2021.747472https://doaj.org/article/a593ecf1ae644e6eb6e9473a8df3cf0f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncir.2021.747472/fullhttps://doaj.org/toc/1662-5110Sensory systems have to be malleable to context-dependent modulations occurring over different time scales, in order to serve their evolutionary function of informing about the external world while also eliciting survival-promoting behaviors. Stress is a major context-dependent signal that can have fast and delayed effects on sensory systems, especially on the auditory system. Urocortin 3 (UCN3) is a member of the corticotropin-releasing factor family. As a neuropeptide, UCN3 regulates synaptic activity much faster than the classic steroid hormones of the hypothalamic-pituitary-adrenal axis. Moreover, due to the lack of synaptic re-uptake mechanisms, UCN3 can have more long-lasting and far-reaching effects. To date, a modest number of studies have reported the presence of UCN3 or its receptor CRFR2 in the auditory system, particularly in the cochlea and the superior olivary complex, and have highlighted the importance of this stress neuropeptide for protecting auditory function. However, a comprehensive map of all neurons synthesizing UCN3 or CRFR2 within the auditory pathway is lacking. Here, we utilize two reporter mouse lines to elucidate the expression patterns of UCN3 and CRFR2 in the auditory system. Additional immunolabelling enables further characterization of the neurons that synthesize UCN3 or CRFR2. Surprisingly, our results indicate that within the auditory system, UCN3 is expressed predominantly in principal cells, whereas CRFR2 expression is strongest in non-principal, presumably multisensory, cell types. Based on the presence or absence of overlap between UCN3 and CRFR2 labeling, our data suggest unusual modes of neuromodulation by UCN3, involving volume transmission and autocrine signaling.Sara PagellaJan M. DeussingConny Kopp-ScheinpflugFrontiers Media S.A.articleurocortinCRFR2auditorystress signalingmultimodalvolume transmissionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neural Circuits, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urocortin CRFR2 auditory stress signaling multimodal volume transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	urocortin CRFR2 auditory stress signaling multimodal volume transmission Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Sara Pagella Jan M. Deussing Conny Kopp-Scheinpflug Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
description	Sensory systems have to be malleable to context-dependent modulations occurring over different time scales, in order to serve their evolutionary function of informing about the external world while also eliciting survival-promoting behaviors. Stress is a major context-dependent signal that can have fast and delayed effects on sensory systems, especially on the auditory system. Urocortin 3 (UCN3) is a member of the corticotropin-releasing factor family. As a neuropeptide, UCN3 regulates synaptic activity much faster than the classic steroid hormones of the hypothalamic-pituitary-adrenal axis. Moreover, due to the lack of synaptic re-uptake mechanisms, UCN3 can have more long-lasting and far-reaching effects. To date, a modest number of studies have reported the presence of UCN3 or its receptor CRFR2 in the auditory system, particularly in the cochlea and the superior olivary complex, and have highlighted the importance of this stress neuropeptide for protecting auditory function. However, a comprehensive map of all neurons synthesizing UCN3 or CRFR2 within the auditory pathway is lacking. Here, we utilize two reporter mouse lines to elucidate the expression patterns of UCN3 and CRFR2 in the auditory system. Additional immunolabelling enables further characterization of the neurons that synthesize UCN3 or CRFR2. Surprisingly, our results indicate that within the auditory system, UCN3 is expressed predominantly in principal cells, whereas CRFR2 expression is strongest in non-principal, presumably multisensory, cell types. Based on the presence or absence of overlap between UCN3 and CRFR2 labeling, our data suggest unusual modes of neuromodulation by UCN3, involving volume transmission and autocrine signaling.
format	article
author	Sara Pagella Jan M. Deussing Conny Kopp-Scheinpflug
author_facet	Sara Pagella Jan M. Deussing Conny Kopp-Scheinpflug
author_sort	Sara Pagella
title	Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
title_short	Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
title_full	Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
title_fullStr	Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
title_full_unstemmed	Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System
title_sort	expression patterns of the neuropeptide urocortin 3 and its receptor crfr2 in the mouse central auditory system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a593ecf1ae644e6eb6e9473a8df3cf0f
work_keys_str_mv	AT sarapagella expressionpatternsoftheneuropeptideurocortin3anditsreceptorcrfr2inthemousecentralauditorysystem AT janmdeussing expressionpatternsoftheneuropeptideurocortin3anditsreceptorcrfr2inthemousecentralauditorysystem AT connykoppscheinpflug expressionpatternsoftheneuropeptideurocortin3anditsreceptorcrfr2inthemousecentralauditorysystem
_version_	1718431127637590016

Expression Patterns of the Neuropeptide Urocortin 3 and Its Receptor CRFR2 in the Mouse Central Auditory System

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