Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection

Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB deficiency specifically impairs thymic negative s...

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Autores principales:	Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a59967540154488a8bba0887e70baf97
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spelling	oai:doaj.org-article:a59967540154488a8bba0887e70baf972021-12-02T15:35:07ZIdentification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection10.1038/s41467-019-10525-12041-1723https://doaj.org/article/a59967540154488a8bba0887e70baf972019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10525-1https://doaj.org/toc/2041-1723Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB deficiency specifically impairs thymic negative selection without affecting peripheral T cell homeostasis.Miki Arai HojoKyoko MasudaHiroaki HojoYosuke NagahataKeiko YasudaDaiya OharaYusuke TakeuchiKeiji HirotaYutaka SuzukiHiroshi KawamotoShinpei KawaokaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miki Arai Hojo Kyoko Masuda Hiroaki Hojo Yosuke Nagahata Keiko Yasuda Daiya Ohara Yusuke Takeuchi Keiji Hirota Yutaka Suzuki Hiroshi Kawamoto Shinpei Kawaoka Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
description	Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB deficiency specifically impairs thymic negative selection without affecting peripheral T cell homeostasis.
format	article
author	Miki Arai Hojo Kyoko Masuda Hiroaki Hojo Yosuke Nagahata Keiko Yasuda Daiya Ohara Yusuke Takeuchi Keiji Hirota Yutaka Suzuki Hiroshi Kawamoto Shinpei Kawaoka
author_facet	Miki Arai Hojo Kyoko Masuda Hiroaki Hojo Yosuke Nagahata Keiko Yasuda Daiya Ohara Yusuke Takeuchi Keiji Hirota Yutaka Suzuki Hiroshi Kawamoto Shinpei Kawaoka
author_sort	Miki Arai Hojo
title	Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
title_short	Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
title_full	Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
title_fullStr	Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
title_full_unstemmed	Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
title_sort	identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a59967540154488a8bba0887e70baf97
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Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection

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