Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.

Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using w...

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Autores principales:	Jiapeng Lu, Yuqing Huang, Youxin Wang, Yan Li, Yujun Zhang, Jingjing Wu, Feifei Zhao, Shijiao Meng, Xinwei Yu, Qingwei Ma, Manshu Song, Naibai Chang, Alan H Bittles, Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a599848cba954a7c942160fd2db00985
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spelling	oai:doaj.org-article:a599848cba954a7c942160fd2db009852021-11-18T07:13:28ZProfiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.1932-620310.1371/journal.pone.0039726https://doaj.org/article/a599848cba954a7c942160fd2db009852012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22802942/?tool=EBIhttps://doaj.org/toc/1932-6203Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.Jiapeng LuYuqing HuangYouxin WangYan LiYujun ZhangJingjing WuFeifei ZhaoShijiao MengXinwei YuQingwei MaManshu SongNaibai ChangAlan H BittlesWei WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e39726 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiapeng Lu Yuqing Huang Youxin Wang Yan Li Yujun Zhang Jingjing Wu Feifei Zhao Shijiao Meng Xinwei Yu Qingwei Ma Manshu Song Naibai Chang Alan H Bittles Wei Wang Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
description	Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
format	article
author	Jiapeng Lu Yuqing Huang Youxin Wang Yan Li Yujun Zhang Jingjing Wu Feifei Zhao Shijiao Meng Xinwei Yu Qingwei Ma Manshu Song Naibai Chang Alan H Bittles Wei Wang
author_facet	Jiapeng Lu Yuqing Huang Youxin Wang Yan Li Yujun Zhang Jingjing Wu Feifei Zhao Shijiao Meng Xinwei Yu Qingwei Ma Manshu Song Naibai Chang Alan H Bittles Wei Wang
author_sort	Jiapeng Lu
title	Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
title_short	Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
title_full	Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
title_fullStr	Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
title_full_unstemmed	Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
title_sort	profiling plasma peptides for the identification of potential ageing biomarkers in chinese han adults.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a599848cba954a7c942160fd2db00985
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Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.

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