Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging

Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging

Jianxin Liu,1,* Tingting Shang,1,* Fengjuan Wang,1 Yang Cao,1 Lan Hao,1 JianLi Ren,1,2 Haitao Ran,1,2 Zhigang Wang,1,2 Pan Li,1,2 Zhiyu Du3 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2Department of Ultrasound, 3Postgraduate Department, The Second Affiliated Hospital of Chongqing Med...

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Autores principales: Liu J, Shang T, Wang F, Cao Y, Hao L, Ren J, Ran H, Wang Z, Li P, Du Z
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
low-intensity focused ultrasound
perfluoropentane nanodroplets
acoustic droplet vaporization
ultrasound molecular imaging
targeting
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/a59d334d57d344e595c2f9d4f07ccc7b
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spelling oai:doaj.org-article:a59d334d57d344e595c2f9d4f07ccc7b2021-12-02T05:03:09ZLow-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging1178-2013https://doaj.org/article/a59d334d57d344e595c2f9d4f07ccc7b2017-01-01T00:00:00Zhttps://www.dovepress.com/low-intensity-focused-ultrasound-lifu-induced-acoustic-droplet-vaporiz-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jianxin Liu,1,* Tingting Shang,1,* Fengjuan Wang,1 Yang Cao,1 Lan Hao,1 JianLi Ren,1,2 Haitao Ran,1,2 Zhigang Wang,1,2 Pan Li,1,2 Zhiyu Du3 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2Department of Ultrasound, 3Postgraduate Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China *These authors contributed equally to this work Abstract: The commonly used ultrasound (US) molecular probes, such as targeted microbubbles and perfluorocarbon emulsions, present a number of inherent problems including the conflict between US visualization and particle penetration. This study describes the successful fabrication of phase changeable folate-targeted perfluoropentane nanodroplets (termed FA-NDs), a novel US molecular probe for tumor molecular imaging with US. Notably, these FA-NDs can be triggered by low-intensity focused US (LIFU) sonication, providing excellent US enhancement in B-mode and contrast-enhanced US mode in vitro. After intravenous administration into nude mice bearing SKOV3 ovarian carcinomas, 1,1'-dioctadecyl-3,3,3',3' -tetramethylindotricarbocyanine iodide-labeled FA-NDs were found to accumulate in the tumor region. FA-NDs injection followed by LIFU sonication exhibited remarkable US contrast enhancement in the tumor region. In conclusion, combining our elaborately developed FA-NDs with LIFU sonication provides a potential protocol for US molecular imaging in folate receptor-overexpressing tumors. Keywords: low-intensity focused ultrasound, perfluoropentane nanodroplets, acoustic droplet vaporization, ultrasound molecular imaging, targetingLiu JShang TWang FCao YHao LRen JRan HWang ZLi PDu ZDove Medical Pressarticlelow-intensity focused ultrasoundperfluoropentane nanodropletsacoustic droplet vaporizationultrasound molecular imagingtargetingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 911-923 (2017)
institution DOAJ
collection DOAJ
language EN
topic low-intensity focused ultrasound
perfluoropentane nanodroplets
acoustic droplet vaporization
ultrasound molecular imaging
targeting
Medicine (General)
R5-920
spellingShingle low-intensity focused ultrasound
perfluoropentane nanodroplets
acoustic droplet vaporization
ultrasound molecular imaging
targeting
Medicine (General)
R5-920
Liu J
Shang T
Wang F
Cao Y
Hao L
Ren J
Ran H
Wang Z
Li P
Du Z
Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
description Jianxin Liu,1,* Tingting Shang,1,* Fengjuan Wang,1 Yang Cao,1 Lan Hao,1 JianLi Ren,1,2 Haitao Ran,1,2 Zhigang Wang,1,2 Pan Li,1,2 Zhiyu Du3 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2Department of Ultrasound, 3Postgraduate Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China *These authors contributed equally to this work Abstract: The commonly used ultrasound (US) molecular probes, such as targeted microbubbles and perfluorocarbon emulsions, present a number of inherent problems including the conflict between US visualization and particle penetration. This study describes the successful fabrication of phase changeable folate-targeted perfluoropentane nanodroplets (termed FA-NDs), a novel US molecular probe for tumor molecular imaging with US. Notably, these FA-NDs can be triggered by low-intensity focused US (LIFU) sonication, providing excellent US enhancement in B-mode and contrast-enhanced US mode in vitro. After intravenous administration into nude mice bearing SKOV3 ovarian carcinomas, 1,1'-dioctadecyl-3,3,3',3' -tetramethylindotricarbocyanine iodide-labeled FA-NDs were found to accumulate in the tumor region. FA-NDs injection followed by LIFU sonication exhibited remarkable US contrast enhancement in the tumor region. In conclusion, combining our elaborately developed FA-NDs with LIFU sonication provides a potential protocol for US molecular imaging in folate receptor-overexpressing tumors. Keywords: low-intensity focused ultrasound, perfluoropentane nanodroplets, acoustic droplet vaporization, ultrasound molecular imaging, targeting
format article
author Liu J
Shang T
Wang F
Cao Y
Hao L
Ren J
Ran H
Wang Z
Li P
Du Z
author_facet Liu J
Shang T
Wang F
Cao Y
Hao L
Ren J
Ran H
Wang Z
Li P
Du Z
author_sort Liu J
title Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
title_short Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
title_full Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
title_fullStr Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
title_full_unstemmed Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
title_sort low-intensity focused ultrasound (lifu)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/a59d334d57d344e595c2f9d4f07ccc7b
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AT shangt lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
AT wangf lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
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AT haol lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
AT renj lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
AT ranh lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
AT wangz lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
AT lip lowintensityfocusedultrasoundlifuinducedacousticdropletvaporizationinphasetransitionperfluoropentanenanodropletsmodifiedbyfolateforultrasoundmolecularimaging
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