B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.

Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that ex...

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Autores principales:	Yuri Kasama, Takuo Mizukami, Hideki Kusunoki, Jan Peveling-Oberhag, Yasumasa Nishito, Makoto Ozawa, Michinori Kohara, Toshiaki Mizuochi, Kyoko Tsukiyama-Kohara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5a0b362ce5b4067af2f69fdf7a1e88a
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spelling	oai:doaj.org-article:a5a0b362ce5b4067af2f69fdf7a1e88a2021-11-18T08:27:05ZB-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.1932-620310.1371/journal.pone.0091373https://doaj.org/article/a5a0b362ce5b4067af2f69fdf7a1e88a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651473/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-developing HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analysed by genome-wide microarray. In BCLs from HCV-Tg mice, the expression of various genes was modified, and for some genes, expression was influenced by the gender of the animals. Markedly modified genes such as Fos, C3, LTβR, A20, NF-κB and miR-26b in BCLs were further characterised using specific assays. We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.Yuri KasamaTakuo MizukamiHideki KusunokiJan Peveling-OberhagYasumasa NishitoMakoto OzawaMichinori KoharaToshiaki MizuochiKyoko Tsukiyama-KoharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e91373 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuri Kasama Takuo Mizukami Hideki Kusunoki Jan Peveling-Oberhag Yasumasa Nishito Makoto Ozawa Michinori Kohara Toshiaki Mizuochi Kyoko Tsukiyama-Kohara B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
description	Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extrahepatic disorders such as B-cell non-Hodgkin's lymphoma (B-NHL). To reveal the molecular signalling pathways responsible for HCV-associated B-NHL development, we utilised transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-developing HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analysed by genome-wide microarray. In BCLs from HCV-Tg mice, the expression of various genes was modified, and for some genes, expression was influenced by the gender of the animals. Markedly modified genes such as Fos, C3, LTβR, A20, NF-κB and miR-26b in BCLs were further characterised using specific assays. We propose that activation of both canonical and alternative NF-κB signalling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.
format	article
author	Yuri Kasama Takuo Mizukami Hideki Kusunoki Jan Peveling-Oberhag Yasumasa Nishito Makoto Ozawa Michinori Kohara Toshiaki Mizuochi Kyoko Tsukiyama-Kohara
author_facet	Yuri Kasama Takuo Mizukami Hideki Kusunoki Jan Peveling-Oberhag Yasumasa Nishito Makoto Ozawa Michinori Kohara Toshiaki Mizuochi Kyoko Tsukiyama-Kohara
author_sort	Yuri Kasama
title	B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
title_short	B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
title_full	B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
title_fullStr	B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
title_full_unstemmed	B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
title_sort	b-cell-intrinsic hepatitis c virus expression leads to b-cell-lymphomagenesis and induction of nf-κb signalling.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a5a0b362ce5b4067af2f69fdf7a1e88a
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B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.

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